Reduced levels of MMP-2 and TIMP-1 in dyssegmental dysplasia

Kiyoshi Uchide, Hirohisa Ueno, Noboru Takizawa, Yasunori Okada

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) were measured in a mild case of dyssegmental dysplasia. X-ray pictures of a female baby born vaginally at 39 weeks of gestation showed short, bent, dumbbell-shaped long bones of the limbs and profound dyssegmental ossification in the spine, findings characteristic of dyssegmental dysplasia. When the levels of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were measured, the levels of MMP-2 and TIMP-1 were significantly reduced. This case might provide a clue to disclose the etiology of dyssegmental dysplasia.

Original languageEnglish
Pages (from-to)381-382
Number of pages2
JournalJournal of Bone and Mineral Research
Issue number2
Publication statusPublished - 2003 Feb 1
Externally publishedYes


  • Bone
  • Congenital anomaly
  • Dyssegmental dysplasia
  • Matrix metalloproteinases
  • Tissue inhibitors of metalloproteinases

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine


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