Reduced levels of MMP-2 and TIMP-1 in dyssegmental dysplasia

Kiyoshi Uchide; Hirohisa Ueno; Noboru Takizawa; Yasunori Okada

doi:10.1359/jbmr.2003.18.2.381

Reduced levels of MMP-2 and TIMP-1 in dyssegmental dysplasia

Kiyoshi Uchide, Hirohisa Ueno, Noboru Takizawa, Yasunori Okada

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) were measured in a mild case of dyssegmental dysplasia. X-ray pictures of a female baby born vaginally at 39 weeks of gestation showed short, bent, dumbbell-shaped long bones of the limbs and profound dyssegmental ossification in the spine, findings characteristic of dyssegmental dysplasia. When the levels of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were measured, the levels of MMP-2 and TIMP-1 were significantly reduced. This case might provide a clue to disclose the etiology of dyssegmental dysplasia.

Original language	English
Pages (from-to)	381-382
Number of pages	2
Journal	Journal of Bone and Mineral Research
Volume	18
Issue number	2
DOIs	https://doi.org/10.1359/jbmr.2003.18.2.381
Publication status	Published - 2003 Feb 1
Externally published	Yes

Keywords

Bone
Congenital anomaly
Dyssegmental dysplasia
Matrix metalloproteinases
Tissue inhibitors of metalloproteinases

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1359/jbmr.2003.18.2.381

Cite this

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abstract = "Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) were measured in a mild case of dyssegmental dysplasia. X-ray pictures of a female baby born vaginally at 39 weeks of gestation showed short, bent, dumbbell-shaped long bones of the limbs and profound dyssegmental ossification in the spine, findings characteristic of dyssegmental dysplasia. When the levels of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were measured, the levels of MMP-2 and TIMP-1 were significantly reduced. This case might provide a clue to disclose the etiology of dyssegmental dysplasia.",

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AU - Uchide, Kiyoshi

AU - Ueno, Hirohisa

AU - Takizawa, Noboru

AU - Okada, Yasunori

PY - 2003/2/1

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AB - Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) were measured in a mild case of dyssegmental dysplasia. X-ray pictures of a female baby born vaginally at 39 weeks of gestation showed short, bent, dumbbell-shaped long bones of the limbs and profound dyssegmental ossification in the spine, findings characteristic of dyssegmental dysplasia. When the levels of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were measured, the levels of MMP-2 and TIMP-1 were significantly reduced. This case might provide a clue to disclose the etiology of dyssegmental dysplasia.

KW - Bone

KW - Congenital anomaly

KW - Dyssegmental dysplasia

KW - Matrix metalloproteinases

KW - Tissue inhibitors of metalloproteinases

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Reduced levels of MMP-2 and TIMP-1 in dyssegmental dysplasia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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