Reduced p27(Kip1) expression in hepatocellular carcinomas

Ai Min Hui, Lin Sun, Yae Kanai, Michiie Sakamoto, Setsuo Hirohashi

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


This study was designed to determine whether changes in p27(Kip1) expression are involved in human hepatocarcinogenesis. We examined the p27(Kip1) mRNA expression in hepatocellular carcinomas and surrounding non-cancerous liver tissue samples from 21 patients using a reverse-transcriptase polymerase chain reaction assay. The mean p27(Kip1) mRNA expression levels (ratio of p27(Kip1)/β-actin mRNA) were significantly lower in hepatocellular carcinomas than in non-cancerous liver tissues (0.49±0.24 versus 0.57±0.22, P<0.05). p27(Kip1) mRNA expression was reduced in 11 (52%) of the 21 hepatocellular carcinomas when compared with the surrounding non-cancerous liver tissues. These findings suggest that reduced p27(Kip1) expression may be at least partly responsible for human hepatocarcinogenesis. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalCancer Letters
Issue number1-2
Publication statusPublished - 1998 Oct 23
Externally publishedYes


  • Cell cycle regulation
  • Cyclin-dependent kinase inhibitor
  • Hepatocellular carcinoma
  • p27(Kip1)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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