Reevaluation of Makuuchi’s criteria for resecting hepatocellular carcinoma: A Japanese nationwide survey

Osamu Aramaki, Tadatoshi Takayama, Yutaka Matsuyama, Shoji Kubo, Norihiro Kokudo, Masayuki Kurosaki, Takamichi Murakami, Shuichiro Shiina, Masatoshi Kudo, Michiie Sakamoto, Osamu Nakashima, Takumi Fukumoto, Hiroko Iijima, Susumu Eguchi, Yuji Soejima, Masatoshi Makuuchi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Aim: Although Makuuchi’s criteria are widely used to determine the cut-off for safe liver resection, there have been few reports of concrete data supporting their validity. Here, we verified the utility of Makuuchi’s criteria by comparing the operative mortality rates associated with liver resection between hepatocellular carcinoma (HCC) patients meeting or exceeding the criteria. Methods: A database was built using data from 15 597 patients treated between 2000 and 2007 for whom values for all three variables included in Makuuchi’s criteria for liver resection (clinical ascites, serum bilirubin, and indocyanine green clearance) were available. The patients were divided into those fulfilling (n = 12 175) or exceeding (n = 3422) the criteria. The postoperative mortality (death for any reason within 30 days) and long-term survival were compared between the two groups. Results: The operative mortality rate was significantly lower in patients meeting the criteria than in those exceeding the criteria (1.07% vs. 2.01%, respectively; p < 0.001). On multivariate analysis, exceeded the criteria was significantly associated with the risk for operative mortality (relative risk 2.08; 95% confidence interval (CI), 1.23–3.52; p = 0.007). Surgical indication meeting or exceeding the criteria was an independent factor for overall survival (hazard ratio 1.27; 95% CI, 1.18–1.36; p < 0.001). Conclusion: Makuuchi’s criteria are suitable for determining the indication for resection of HCC due to the reduction in risk of operative mortality.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalHepatology Research
Issue number2
Publication statusPublished - 2023 Feb


  • Japanese nationwide survey
  • Makuuchi’s criteria
  • hepatocellular carcinoma
  • mortality
  • resection

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases


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