Regional anesthesia and cancer immunology

Toru Igarashi, Katsuya Mori, Kei Inoue, Takeshi Suzuki, Hiroshi Morisaki

Research output: Contribution to journalReview articlepeer-review


Regional anesthesia has been widely applied as an excellent method for perioperative analgesia. Recent studies suggested that regional anesthesia is a promising approach to minimize the risk of surgical site infection and postoperative cancer recurrence, subsequently providing the benefits to the long-term outcome. In particular, it is of great interest that regional anesthesia might be able to reduce cancer recurrence. In cancer patients, innate immunity against cancer could be depressed, resulting in the predisposition to evoke metastasis. Besides, during the perioperative periods, tumor immunity is significantly depressed due to surgical pain, activation of sympathetic nervous system, inflammatory responses, and others. In this review article, we discuss the tumor immunity during the perioperative period, with focus on the alterations of tumor immunity and regional anesthesia.

Original languageEnglish
Pages (from-to)1097-1105
Number of pages9
JournalJapanese Journal of Anesthesiology
Issue number9
Publication statusPublished - 2013 Sept 1


  • Cancer immunity
  • Long-time prognosis
  • Regional anesthesia

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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