Regulation of cytokine signaling and inflammation

Toshitkatsu Hanada, Akihiko Yoshimura

Research output: Contribution to journalReview articlepeer-review

606 Citations (Scopus)


Inflammation progresses by the action of pro-inflammatory cytokines, including interleukin-1 (IL-1), the tumor necrosis factor (TNF), gamma-interferon (IFNγ), IL-12, IL-18, and the granulocyte-macrophage colony-stimulating factor, and is resolved by anti-inflammatory cytokines such as IL-4, IL-10, IL-13, IFNα, and the transforming growth factor (TGF)β. The intracellular signal transduction pathways of these cytokines have been studied extensively, and these pathways ultimately activate transcription factors, such as NF-κB, Smad, and STATs. Recently, the negative -feedback regulation of these pathways has been identified. In this review, we provide examples of the relationship between cytokine signal transduction, negative-signal regulation, and inflammatory disease models. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.

Original languageEnglish
Pages (from-to)413-421
Number of pages9
JournalCytokine and Growth Factor Reviews
Issue number4-5
Publication statusPublished - 2002 Aug 1
Externally publishedYes


  • Cytokine signaling
  • Inflammation
  • Interleukin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)


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