Regulation of Th17 cell differentiation by intestinal commensal bacteria

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12 Citations (Scopus)


Interleukin (IL)-17-producing CD4 T cells ('Th17 cells') are most abundant at the intestinal mucosa, and play a critical role in the maintenance of mucosal barrier function. Recent studies indicate that accumulation of intestinal Th17 cells depends on stimulation by intestinal commensal bacteria - particularly by segmented filamentous bacterium. In this review, we summarise recent advances in our understanding of the mechanisms of intestinal Th17 synthesis in mice, and discuss their relevance to infectious and inflammatory diseases.

Original languageEnglish
Pages (from-to)327-334
Number of pages8
JournalBeneficial Microbes
Issue number4
Publication statusPublished - 2010


  • Infectious and inflammatory disease
  • Interleukin
  • Mucosal barrier
  • Th17 synthesis

ASJC Scopus subject areas

  • General Medicine


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