Regulation of thermoresponsive properties and drug carrier application of nano-micelles via heterogeneous end-functional block copolymer blends

Masamichi Nakayama; Yayoi Kawahara; Hideko Kanazawa; Teruo Okano

Regulation of thermoresponsive properties and drug carrier application of nano-micelles via heterogeneous end-functional block copolymer blends

Masamichi Nakayama, Yayoi Kawahara, Hideko Kanazawa, Teruo Okano

School of Pharmaceutical Sciences

Research output: Contribution to conference › Paper › peer-review

Abstract

We prepared well-defined amphiphilic diblock copolymers comprising thermoresponsive segments and hydrophobic segments by reversible addition-fragmentation chain transfer radical polymerization. Terminal dithiobenzoate groups located at thermoresponsive chains were substituted with hydrophilic maleimede groups. Polymeric micelles were prepared by blend of heterogeneous end-functional diblock copolymers at any ratio in weight, and were characterized regading hydrodynamic diameters and thermoresponsive properties.

Original language	English
Pages	5455-5456
Number of pages	2
Publication status	Published - 2006 Dec 1
Event	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: 2006 Sept 20 → 2006 Sept 22

Other

Other	55th Society of Polymer Science Japan Symposium on Macromolecules
Country/Territory	Japan
City	Toyama
Period	06/9/20 → 06/9/22

Keywords

Drug carrier
Poly(N-isopropylacrylamide)
Polymer blend
Polymeric micelle
Reversible addition-fragmentation chain transfer radical polymerization
Thermoresponse

ASJC Scopus subject areas

Engineering(all)

Cite this

Regulation of thermoresponsive properties and drug carrier application of nano-micelles via heterogeneous end-functional block copolymer blends. / Nakayama, Masamichi; Kawahara, Yayoi; Kanazawa, Hideko et al.
2006. 5455-5456 Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.

Research output: Contribution to conference › Paper › peer-review

@conference{fd8b1f2cc01d4255af25f720d75fb52a,

title = "Regulation of thermoresponsive properties and drug carrier application of nano-micelles via heterogeneous end-functional block copolymer blends",

abstract = "We prepared well-defined amphiphilic diblock copolymers comprising thermoresponsive segments and hydrophobic segments by reversible addition-fragmentation chain transfer radical polymerization. Terminal dithiobenzoate groups located at thermoresponsive chains were substituted with hydrophilic maleimede groups. Polymeric micelles were prepared by blend of heterogeneous end-functional diblock copolymers at any ratio in weight, and were characterized regading hydrodynamic diameters and thermoresponsive properties.",

keywords = "Drug carrier, Poly(N-isopropylacrylamide), Polymer blend, Polymeric micelle, Reversible addition-fragmentation chain transfer radical polymerization, Thermoresponse",

author = "Masamichi Nakayama and Yayoi Kawahara and Hideko Kanazawa and Teruo Okano",

year = "2006",

month = dec,

day = "1",

language = "English",

pages = "5455--5456",

note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

}

TY - CONF

T1 - Regulation of thermoresponsive properties and drug carrier application of nano-micelles via heterogeneous end-functional block copolymer blends

AU - Nakayama, Masamichi

AU - Kawahara, Yayoi

AU - Kanazawa, Hideko

AU - Okano, Teruo

PY - 2006/12/1

Y1 - 2006/12/1

N2 - We prepared well-defined amphiphilic diblock copolymers comprising thermoresponsive segments and hydrophobic segments by reversible addition-fragmentation chain transfer radical polymerization. Terminal dithiobenzoate groups located at thermoresponsive chains were substituted with hydrophilic maleimede groups. Polymeric micelles were prepared by blend of heterogeneous end-functional diblock copolymers at any ratio in weight, and were characterized regading hydrodynamic diameters and thermoresponsive properties.

AB - We prepared well-defined amphiphilic diblock copolymers comprising thermoresponsive segments and hydrophobic segments by reversible addition-fragmentation chain transfer radical polymerization. Terminal dithiobenzoate groups located at thermoresponsive chains were substituted with hydrophilic maleimede groups. Polymeric micelles were prepared by blend of heterogeneous end-functional diblock copolymers at any ratio in weight, and were characterized regading hydrodynamic diameters and thermoresponsive properties.

KW - Drug carrier

KW - Poly(N-isopropylacrylamide)

KW - Polymer blend

KW - Polymeric micelle

KW - Reversible addition-fragmentation chain transfer radical polymerization

KW - Thermoresponse

UR - http://www.scopus.com/inward/record.url?scp=33846181044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846181044&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33846181044

SP - 5455

EP - 5456

T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -

Regulation of thermoresponsive properties and drug carrier application of nano-micelles via heterogeneous end-functional block copolymer blends

Abstract

Other

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this