Regulatory interaction between CFTR and the SLC26 transporters

Nikolay Shcheynikov, Shigeru B.H. Ko, Weizhong Zeng, Young Choi Joo, Michael R. Dorwart, Philip J. Thomas, Shmuel Muallem

Research output: Chapter in Book/Report/Conference proceedingConference contribution

55 Citations (Scopus)


Most epithelia that express CFTR secrete fluid rich in HCO3 - and poor in Cl- that is generated by a CFTR-dependent Cl- absorption and HCO3- secretion process that when aberrant leads to human diseases such as cystic fibrosis and congenital chloride diarrhoea. Epithelial Cl- absorption and HCO 3- secretion require expression of CFTR and other Cl - and HCO3- transporters in the luminal membrane of the secreting cells. Recent advances in understanding this critical epithelial function revealed that the luminal Cl- and HCO 3- transporters are members of the SLC26 family. Characterization of several members of the family reveals that all characterized thus far are electrogenic with an isoform specific Cl-/HCO 3- transport stoichiometry. In vivo these transporters exist in a transporting complex with CFTR. The SLC26 transporters and CFTR are recruited to the complex by binding to scaffolds containing PDZ domains. Upon stimulation and PKA-dependent phosphorylation of CFTR R domain, the R domain binds to the SLC26 transporter STAS domain. Interaction of the R and STAS domains results in a marked and mutual activation of CFTR and the SLC26 transporters. The significance of this mode of regulation to epithelial Cl - absorption and HCO3- secretion is obvious.

Original languageEnglish
Title of host publicationEpithelial Anion Transport in Health and Disease
Subtitle of host publicationThe Role of the SLC26 Transporters Family
Number of pages10
Publication statusPublished - 2006
Externally publishedYes

Publication series

NameNovartis Foundation Symposium
ISSN (Print)1528-2511

ASJC Scopus subject areas

  • General Medicine


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