Regulatory mechanisms of immune responses to intestinal bacteria

K. Honda, K. Takeda

Research output: Contribution to journalReview articlepeer-review

88 Citations (Scopus)


The intestinal mucosa allows the residence of trillions of bacteria with which it interacts dynamically. To establish and maintain a mutually beneficial relationship, the mucosal immune system must enforce tolerance toward the vast non-pathogenic microbiota while simultaneously remaining reactive to potentially pathogenic microbes; the disruption of this delicate balance results in inflammatory bowel diseases. In this review, we describe advances in our understanding of regulatory mechanisms of the innate immune system and how these shape adaptive immune systems during steady-state and inflammatory processes in the intestinal mucosa.

Original languageEnglish
Pages (from-to)187-196
Number of pages10
JournalMucosal Immunology
Issue number3
Publication statusPublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Regulatory mechanisms of immune responses to intestinal bacteria'. Together they form a unique fingerprint.

Cite this