Regulatory T cells and inflammatory bowel diseases

Takanori Kanai, Mamoru Watanabe

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Crohn’s disease and ulcerative colitis are two major forms of human inflammatory bowel diseases (IBD). Their etiology is unknown, but increasing evidence indicate that immune mechanisms play an important role. It is well known that immune responses in the intestine remain in a state of controlled inflammation, suggesting that not only active suppression by regulatory T (TR) cells plays an important role in the normal intestinal homeostasis, but also its dysregula-tion leads to the development of IBD. This article reviews the unique aspects of TR cells and discuss how these control the intestinal homeostasis.

Original languageEnglish
Pages (from-to)302-308
Number of pages7
JournalJapanese Journal of Clinical Immunology
Issue number5
Publication statusPublished - 2004
Externally publishedYes


  • Bacterial flora
  • Immune regulation
  • Inflammatory bowel disease
  • Regulatory T cell
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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