Relation between structures and functions of gel-like nanoparticles with thermo-responsitiveness

Masatoshi Narikawa, Keiji Fujimoto

Research output: Contribution to conferencePaperpeer-review


To design nanoparticles of a stimuli-sensitive gel, we prepared a copolymer having both thermo-responsitiveness and reactivity. The copolymers were obtained by solution polymerization with N-isopropylacrylamide and N-methacryloxysuccinimide, and they were allowed to react with cystamine and were reduced to introduce sulfhydryl groups. The obtained polymers were precipitated to form nanoparticles by raising temperature, and then nanoparticles were cross-linked with disulfide bonds. The nanoparticle could be disrupted by the breakage of disulfide bonds when the reducing reagents were added. This behavior was related to the molecular size of reducing agents. Macromolecules like proteins could be incorporated into the particles to a higher degree than small molecules. This is because nanoparticles were gel-like and their cross-linking density was relatively low.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27


Other54th SPSJ Annual Meeting 2005


  • Disulfide bonding
  • Gel particles
  • Nanoparticles

ASJC Scopus subject areas

  • General Engineering


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