Relation of home blood pressure to body weight in young normotensive men with or without family history of hypertension

We investigated the relation between home blood pressure (BP) and body weight in 38 young normotensive men (mean age, 16 years) whose parents were normotensive (PNT group) and 34 age- and sex-matched normotensive men, one or both of whose parents were hypertensive (PHT group). Although casual BP measurements were similar in both groups, home systolic BP was significantly higher in the PHT group (123 ± 1 mm Hg) than in the PNT group (116 ± 1 mm Hg). Body weight was significantly greater in the PHT group (66.0 ± 1.4 v 61.8 ± 1.3 kg, P < .05) and body mass index (BMI) was not significantly higher in the PHT group (22.4 ± 0.5 v 21.3 ± 0.5 kg/m², P = .09). Body weight (r = 0.38) and BMI (r = 0.42) were significantly correlated with home systolic BP in the PHT group. There were no differences in serum lipid or uric acid concentrations between the two groups. Our results showed that young normotensive subjects with a genetic predisposition to hypertension weighed more and had higher home systolic BPs compared with subjects without a family history of hypertension. Our observations further indicated a close relationship between a family history of hypertension and increased body weight, even in young normotensive men.