Relationship between hepatitis C virus subtypes and clinical features of liver disease seen in alcoholics

Hirokazu Yokoyama, Hiromasa Ishii, Susumu Moriya, Shigeyuki Nagata, Tetsu Watanabe, Kiyotaka Kamegaya, Hisao Takahashi, Katsuya Maruyama, Paul Haber, Masaharu Tsuchiya

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The influence of hepatitis C virus and its subtypes on the clinical course of liver disease in alcoholics was assessed. Hepatitis C virus infection was confirmed by a reverse transcription and polymerase chain reaction method for the hepatitis C virus NS-5 region in the sera of the alcoholics with various stages of histologically proven liver disease. The frequency of hepatitis C virus was significantly higher in alcoholics with chronic hepatitis (73%) than in those with liver fibrosis (18%), alcoholic hepatitis (17%), and fatty liver (0%). Hepatitis C virus subtypes, namely K1 and K2, were determined by dotblot hybridization analysis of the polymerase chain reaction products with specific probes, and their frequencies were 68% and 32%, respectively. The proportion of patients whose serum transaminase levels returned to normal following 4 weeks of abstinence in hospital was significantly lower in alcoholics with hepatitis C virus viremia (glutamic oxaloacetic transminase: 53.8%; glutamic pyruvic transminase: 42.3%) than in those without viremia (glutamic oxaloacetic transminase: 86.2%, p<0.01; glutamic pyruvic transminase: 89.7%, p<0.01). When alcoholics with the K1 and K2 subtypes of hepatitis C virus were compared, normalization of transminase levels was less frequent in alcoholics with K1 (glutamic oxaloacetic transminase: 42.8%; glutamic pyruvic transminase: 28.6%) than in those with K2 (glutamic oxaloacetic transminase: 88.9%, p<0.05; glutamic pyruvic transmkinase: 77.8%, p<0.05). These data indicate that hepatitis C virus infection is associated with a reduced rate of recovery of serum transminase levels following abstinence in subjects with alcoholic liver disease, more so in the K1 subtype than in the K2 subtype.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalJournal of Hepatology
Issue number2
Publication statusPublished - 1995 Feb


  • Alcoholic liver disese
  • Hepatitis C virus
  • Polymerase chain reaction
  • Subtypes

ASJC Scopus subject areas

  • Hepatology


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