Relationship between unhealthy sleep status and dry eye symptoms in a Japanese population: The JPHC-NEXT study

Akiko Hanyuda; Norie Sawada; Miki Uchino; Motoko Kawashima; Kenya Yuki; Kazuo Tsubota; Kozo Tanno; Kiyomi Sakata; Kazumasa Yamagishi; Hiroyasu Iso; Nobufumi Yasuda; Isao Saito; Tadahiro Kato; Yasuyo Abe; Kazuhiko Arima; Taichi Shimazu; Taiki Yamaji; Atsushi Goto; Manami Inoue; Motoki Iwasaki; Shoichiro Tsugane

doi:10.1016/j.jtos.2021.04.001

Relationship between unhealthy sleep status and dry eye symptoms in a Japanese population: The JPHC-NEXT study

Akiko Hanyuda, Norie Sawada, Miki Uchino, Motoko Kawashima, Kenya Yuki, Kazuo Tsubota, Kozo Tanno, Kiyomi Sakata, Kazumasa Yamagishi, Hiroyasu Iso, Nobufumi Yasuda, Isao Saito, Tadahiro Kato, Yasuyo Abe, Kazuhiko Arima, Taichi Shimazu, Taiki Yamaji, Atsushi Goto, Manami Inoue, Motoki IwasakiShoichiro Tsugane

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Purpose: To investigate whether and how unhealthy sleep habits (i.e., the frequency of difficulty falling or staying asleep, and the frequency of waking up tired) and the duration of sleep are related to the prevalence of dry eye disease (DED) in a general population. Methods: This study included a total of 106,282 subjects aged 40–74 years who participated in a baseline survey of the Japan Public Health Center-based Prospective Study for the Next Generation. DED was defined as the presence of clinically diagnosed DED or severe symptoms. Multivariable-adjusted logistic regression models were used to assess the relationships of various components of sleep status with DED. Results: Higher frequencies of having difficulty falling or staying asleep, and waking up tired were significantly related to increased DED in both sexes (P_trend<0.001). Compared with those with 8 h/day of sleep, shorter sleepers had an increased prevalence of DED in both sexes, although DED was increased among men who slept ≥10 h/day. By comparing participants with the greatest vs. the least difficulty of falling asleep, the multivariable-adjusted odds ratios (95% confidence interval [CI]) were 2.23 (95% CI, 1.99–2.49) for men and 1.91 (95% CI, 1.76–2.07) for women. When analyzed separately, the magnitude of each relationship was stronger with severe DED symptoms than with clinically diagnosed DED. Conclusions: Sleep deprivation and poor sleep quality were significantly related to DED in a Japanese population.

Original language	English
Pages (from-to)	306-312
Number of pages	7
Journal	Ocular Surface
Volume	21
DOIs	https://doi.org/10.1016/j.jtos.2021.04.001
Publication status	Published - 2021 Jul

Keywords

Dry eye disease
Epidemiology
Lifestyle
Ocular disturbance
Sleep deprivation

ASJC Scopus subject areas

Ophthalmology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jtos.2021.04.001

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Hanyuda, A., Sawada, N., Uchino, M., Kawashima, M., Yuki, K., Tsubota, K., Tanno, K., Sakata, K., Yamagishi, K., Iso, H., Yasuda, N., Saito, I., Kato, T., Abe, Y., Arima, K., Shimazu, T., Yamaji, T., Goto, A., Inoue, M., ... Tsugane, S. (2021). Relationship between unhealthy sleep status and dry eye symptoms in a Japanese population: The JPHC-NEXT study. Ocular Surface, 21, 306-312. https://doi.org/10.1016/j.jtos.2021.04.001

Hanyuda, A, Sawada, N, Uchino, M, Kawashima, M, Yuki, K, Tsubota, K, Tanno, K, Sakata, K, Yamagishi, K, Iso, H, Yasuda, N, Saito, I, Kato, T, Abe, Y, Arima, K, Shimazu, T, Yamaji, T, Goto, A, Inoue, M, Iwasaki, M & Tsugane, S 2021, 'Relationship between unhealthy sleep status and dry eye symptoms in a Japanese population: The JPHC-NEXT study', Ocular Surface, vol. 21, pp. 306-312. https://doi.org/10.1016/j.jtos.2021.04.001

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title = "Relationship between unhealthy sleep status and dry eye symptoms in a Japanese population: The JPHC-NEXT study",

abstract = "Purpose: To investigate whether and how unhealthy sleep habits (i.e., the frequency of difficulty falling or staying asleep, and the frequency of waking up tired) and the duration of sleep are related to the prevalence of dry eye disease (DED) in a general population. Methods: This study included a total of 106,282 subjects aged 40–74 years who participated in a baseline survey of the Japan Public Health Center-based Prospective Study for the Next Generation. DED was defined as the presence of clinically diagnosed DED or severe symptoms. Multivariable-adjusted logistic regression models were used to assess the relationships of various components of sleep status with DED. Results: Higher frequencies of having difficulty falling or staying asleep, and waking up tired were significantly related to increased DED in both sexes (Ptrend<0.001). Compared with those with 8 h/day of sleep, shorter sleepers had an increased prevalence of DED in both sexes, although DED was increased among men who slept ≥10 h/day. By comparing participants with the greatest vs. the least difficulty of falling asleep, the multivariable-adjusted odds ratios (95% confidence interval [CI]) were 2.23 (95% CI, 1.99–2.49) for men and 1.91 (95% CI, 1.76–2.07) for women. When analyzed separately, the magnitude of each relationship was stronger with severe DED symptoms than with clinically diagnosed DED. Conclusions: Sleep deprivation and poor sleep quality were significantly related to DED in a Japanese population.",

keywords = "Dry eye disease, Epidemiology, Lifestyle, Ocular disturbance, Sleep deprivation",

author = "Akiko Hanyuda and Norie Sawada and Miki Uchino and Motoko Kawashima and Kenya Yuki and Kazuo Tsubota and Kozo Tanno and Kiyomi Sakata and Kazumasa Yamagishi and Hiroyasu Iso and Nobufumi Yasuda and Isao Saito and Tadahiro Kato and Yasuyo Abe and Kazuhiko Arima and Taichi Shimazu and Taiki Yamaji and Atsushi Goto and Manami Inoue and Motoki Iwasaki and Shoichiro Tsugane",

note = "Funding Information: This study was supported by the National Cancer Center Research and Development Fund (since 2011) and a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan (from 1989 to 2010). Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = jul,

doi = "10.1016/j.jtos.2021.04.001",

language = "English",

volume = "21",

pages = "306--312",

journal = "Ocular Surface",

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TY - JOUR

T1 - Relationship between unhealthy sleep status and dry eye symptoms in a Japanese population

T2 - The JPHC-NEXT study

AU - Hanyuda, Akiko

AU - Sawada, Norie

AU - Uchino, Miki

AU - Kawashima, Motoko

AU - Yuki, Kenya

AU - Tsubota, Kazuo

AU - Tanno, Kozo

AU - Sakata, Kiyomi

AU - Yamagishi, Kazumasa

AU - Iso, Hiroyasu

AU - Yasuda, Nobufumi

AU - Saito, Isao

AU - Kato, Tadahiro

AU - Abe, Yasuyo

AU - Arima, Kazuhiko

AU - Shimazu, Taichi

AU - Yamaji, Taiki

AU - Goto, Atsushi

AU - Inoue, Manami

AU - Iwasaki, Motoki

AU - Tsugane, Shoichiro

N1 - Funding Information: This study was supported by the National Cancer Center Research and Development Fund (since 2011) and a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan (from 1989 to 2010). Publisher Copyright: © 2021

PY - 2021/7

Y1 - 2021/7

N2 - Purpose: To investigate whether and how unhealthy sleep habits (i.e., the frequency of difficulty falling or staying asleep, and the frequency of waking up tired) and the duration of sleep are related to the prevalence of dry eye disease (DED) in a general population. Methods: This study included a total of 106,282 subjects aged 40–74 years who participated in a baseline survey of the Japan Public Health Center-based Prospective Study for the Next Generation. DED was defined as the presence of clinically diagnosed DED or severe symptoms. Multivariable-adjusted logistic regression models were used to assess the relationships of various components of sleep status with DED. Results: Higher frequencies of having difficulty falling or staying asleep, and waking up tired were significantly related to increased DED in both sexes (Ptrend<0.001). Compared with those with 8 h/day of sleep, shorter sleepers had an increased prevalence of DED in both sexes, although DED was increased among men who slept ≥10 h/day. By comparing participants with the greatest vs. the least difficulty of falling asleep, the multivariable-adjusted odds ratios (95% confidence interval [CI]) were 2.23 (95% CI, 1.99–2.49) for men and 1.91 (95% CI, 1.76–2.07) for women. When analyzed separately, the magnitude of each relationship was stronger with severe DED symptoms than with clinically diagnosed DED. Conclusions: Sleep deprivation and poor sleep quality were significantly related to DED in a Japanese population.

AB - Purpose: To investigate whether and how unhealthy sleep habits (i.e., the frequency of difficulty falling or staying asleep, and the frequency of waking up tired) and the duration of sleep are related to the prevalence of dry eye disease (DED) in a general population. Methods: This study included a total of 106,282 subjects aged 40–74 years who participated in a baseline survey of the Japan Public Health Center-based Prospective Study for the Next Generation. DED was defined as the presence of clinically diagnosed DED or severe symptoms. Multivariable-adjusted logistic regression models were used to assess the relationships of various components of sleep status with DED. Results: Higher frequencies of having difficulty falling or staying asleep, and waking up tired were significantly related to increased DED in both sexes (Ptrend<0.001). Compared with those with 8 h/day of sleep, shorter sleepers had an increased prevalence of DED in both sexes, although DED was increased among men who slept ≥10 h/day. By comparing participants with the greatest vs. the least difficulty of falling asleep, the multivariable-adjusted odds ratios (95% confidence interval [CI]) were 2.23 (95% CI, 1.99–2.49) for men and 1.91 (95% CI, 1.76–2.07) for women. When analyzed separately, the magnitude of each relationship was stronger with severe DED symptoms than with clinically diagnosed DED. Conclusions: Sleep deprivation and poor sleep quality were significantly related to DED in a Japanese population.

KW - Dry eye disease

KW - Epidemiology

KW - Lifestyle

KW - Ocular disturbance

KW - Sleep deprivation

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SN - 1542-0124

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JO - Ocular Surface

JF - Ocular Surface

ER -

Relationship between unhealthy sleep status and dry eye symptoms in a Japanese population: The JPHC-NEXT study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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