Relationship of corneal pain sensitivity with dry eye symptoms in dry eye with short tear break-up time

Minako Kaido, Motoko Kawashima, Reiko Ishida, Kazuo Tsubota

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


PURPOSE. The purpose of this prospective comparative study was to investigate corneal sensitivity in subjects with unstable tear film, with and without dry eye (DE) symptoms. METHODS. Forty-one eyes of 41 volunteers (mean age: 45.1 ± 9.4 years; age range, 23–57 years), with normal tear function and ocular surface except for tear stability, were studied. The eyes were divided into two groups depending on the presence or absence of DE symptoms: 21 eyes with DE symptoms (symptomatic group); and 20 eyes without DE symptoms (asymptomatic group). Three types of corneal sensitivity values were measured using a Cochet-Bonnet esthesiometer: the sensitivity for perception of touch (S-touch), the sensitivity for blinking (S-blink), and the sensitivity for pain (S-pain). RESULTS. Mean S-blink and S-pain were significantly higher in the symptomatic group than in the asymptomatic group (P < 0.05), whereas there was no significant difference in mean Stouch between these groups (P > 0.05). CONCLUSIONS. Corneal sensitivity for blinking and pain evoked by increased stimuli was higher in the symptomatic group (subjects with short break-up time DE) compared with subjects who have no DE symptoms despite decreased tear stability. The presence of both tear instability and hyperesthesia, rather than tear instability alone, may contribute to DE pathogenesis.

Original languageEnglish
Pages (from-to)914-919
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Issue number3
Publication statusPublished - 2016 Mar


  • Corneal sensitivity
  • Dry eye
  • Hyperesthesia
  • Tear break-up time
  • Tear film

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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