Renin-angiotensin-aldosterone system in the reproductive system

M. Tanaka, M. Naruse, K. Naruse, A. Tanabe, T. Seki, N. Mishina, K. Tago, A. Arai, H. Demura

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Besides the circulating renin-angiotensin-aldosterone (R-A-A) system, the tissue R-A-A system has been elucidated to play important roles as autocrines and/or paracrines. The components of R-A-A system are expressed in the ovary, uterus and placenta, indicating the existence of the tissue R-A-A system in these organs. The data indicating the involvement of R-A-A system of these tissues into reproduction have been accumulated. AT2 receptors might modulate the initiation and progression of follicle atresia involving granulosa cell apoptosis. AT2 receptors are expressed abundantly in the uterus and decreased during pregnancy. The placental renin are shown to be secreted into the maternal circulation and elevate blood pressure. It is expected to elucidate the significance of the R-A-A system in the reproductive system.

Original languageEnglish
Pages (from-to)1060-1064
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number5
Publication statusPublished - 1999 May
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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