Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses

Yu Sawada, Tetsuya Honda, Sho Hanakawa, Satoshi Nakamizo, Teruasa Murata, Yuri Ueharaguchi-Tanada, Sachiko Ono, Wataru Amano, Saeko Nakajima, Gyohei Egawa, Hideaki Tanizaki, Atsushi Otsuka, Akihiko Kitoh, Teruki Dainichi, Narihito Ogawa, Yuichi Kobayashi, Takehiko Yokomizo, Makoto Arita, Motonobu Nakamura, Yoshiki MiyachiKenji Kabashima

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)


Resolvin E1 (RvE1) is a lipid mediator derived from ?3 polyunsaturated fatty acids that exerts potent antiinflammatory roles in several murine models. The antiinflammatory mechanism of RvE1 in acquired immune responses has been attributed to attenuation of cytokine production by dendritic cells (DCs). In this study, we newly investigated the effect of RvE1 on DC motility using two-photon microscopy in a contact hypersensitivity (CHS) model and found that RvE1 impaired DC motility in the skin. In addition, RvE1 attenuated T cell priming in the draining lymph nodes and effector T cell activation in the skin, which led to the reduced skin inflammation in CHS. In contrast, leukotriene B4 (LTB4) induced actin filament reorganization in DCs and increased DC motility by activating Cdc42 and Rac1 via BLT1, which was abrogated by RvE1. Collectively, our results suggest that RvE1 attenuates cutaneous acquired immune responses by inhibiting cutaneous DC motility, possibly through LTB4-BLT1 signaling blockade.

Original languageEnglish
Pages (from-to)1921-1930
Number of pages10
JournalJournal of Experimental Medicine
Issue number11
Publication statusPublished - 2015 Oct 19
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses'. Together they form a unique fingerprint.

Cite this