TY - JOUR
T1 - Respiratory Distress in Human Metapneumovirus Infection with High-inflammatory Cytokinemia
AU - Takei, Tomoaki
AU - Morozumi, Miyuki
AU - Kadota, Keisuke
AU - Miyamae, Takako
AU - Yokota, Shumpei
AU - Ubukata, Kimiko
AU - Iwata, Satoshi
AU - Takahashi, Takashi
N1 - Funding Information:
The authors have no conflicts of interest to declare in relation to this article. This study was funded, in part, by a grant-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (no. 21390306 to T.T.).
PY - 2012/6
Y1 - 2012/6
N2 - We encountered two human metapneumovirus (HMPV)-infected children who developed respiratory distress due to bronchopneumonia during hospitalization. There was no evidence of abnormal findings in the gastrointestinal or genitourinary tracts or the nervous or mucocutaneous systems. Their respiratory conditions rapidly improved upon the initiation of steroid therapy. Increases and decreases in serum concentrations of various inflammatory cytokines, including interferon-γ, and interleukin-6/10, were evaluated before and after steroid administration. General practitioners should be aware of the possibility of high-inflammatory cytokinemia when examining and treating children with HMPV infection and respiratory distress due to bronchopneumonia.
AB - We encountered two human metapneumovirus (HMPV)-infected children who developed respiratory distress due to bronchopneumonia during hospitalization. There was no evidence of abnormal findings in the gastrointestinal or genitourinary tracts or the nervous or mucocutaneous systems. Their respiratory conditions rapidly improved upon the initiation of steroid therapy. Increases and decreases in serum concentrations of various inflammatory cytokines, including interferon-γ, and interleukin-6/10, were evaluated before and after steroid administration. General practitioners should be aware of the possibility of high-inflammatory cytokinemia when examining and treating children with HMPV infection and respiratory distress due to bronchopneumonia.
KW - Human metapneumovirus
KW - Inflammatory cytokinemia
KW - Real-time reverse transcription-polymerase chain reaction
KW - Respiratory distress
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U2 - 10.1016/j.jecm.2012.04.012
DO - 10.1016/j.jecm.2012.04.012
M3 - Article
AN - SCOPUS:84862015445
SN - 1878-3317
VL - 4
SP - 189
EP - 193
JO - Journal of Experimental and Clinical Medicine
JF - Journal of Experimental and Clinical Medicine
IS - 3
ER -
