TY - JOUR
T1 - Restauro-G
T2 - A Rapid Genome Re-Annotation System for Comparative Genomics
AU - Tamaki, Satoshi
AU - Arakawa, Kazuharu
AU - Kono, Nobuaki
AU - Tomita, Masaru
N1 - Funding Information:
We thank the members of MGSP at the Institute for Advanced Biosciences, Keio University, for critical suggestions. This work was supported by the Japan Society for the Promotion of Science (JSPS).
PY - 2007
Y1 - 2007
N2 - Annotations of complete genome sequences submitted directly from sequencing projects are diverse in terms of annotation strategies and update frequencies. These inconsistencies make comparative studies difficult. To allow rapid data preparation of a large number of complete genomes, automation and speed are important for genome re-annotation. Here we introduce an open-source rapid genome re-annotation software system, Restauro-G, specialized for bacterial genomes. Restauro-G re-annotates a genome by similarity searches utilizing the BLAST-Like Alignment Tool, referring to protein databases such as UniProt KB, NCBI nr, NCBI COGs, Pfam, and PSORTb. Re-annotation by Restauro-G achieved over 98% accuracy for most bacterial chromosomes in comparison with the original manually curated annotation of EMBL releases. Restauro-G was developed in the generic bioinformatics workbench G-language Genome Analysis Environment and is distributed at http://restauro-g.iab.keio.ac.jp/under the GNU General Public License.
AB - Annotations of complete genome sequences submitted directly from sequencing projects are diverse in terms of annotation strategies and update frequencies. These inconsistencies make comparative studies difficult. To allow rapid data preparation of a large number of complete genomes, automation and speed are important for genome re-annotation. Here we introduce an open-source rapid genome re-annotation software system, Restauro-G, specialized for bacterial genomes. Restauro-G re-annotates a genome by similarity searches utilizing the BLAST-Like Alignment Tool, referring to protein databases such as UniProt KB, NCBI nr, NCBI COGs, Pfam, and PSORTb. Re-annotation by Restauro-G achieved over 98% accuracy for most bacterial chromosomes in comparison with the original manually curated annotation of EMBL releases. Restauro-G was developed in the generic bioinformatics workbench G-language Genome Analysis Environment and is distributed at http://restauro-g.iab.keio.ac.jp/under the GNU General Public License.
KW - G-language Genome Analysis Environment
KW - annotation
KW - bioinformatics
KW - complete genomes
KW - software
UR - http://www.scopus.com/inward/record.url?scp=34250180888&partnerID=8YFLogxK
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U2 - 10.1016/S1672-0229(07)60014-X
DO - 10.1016/S1672-0229(07)60014-X
M3 - Article
C2 - 17572364
AN - SCOPUS:34250180888
SN - 1672-0229
VL - 5
SP - 53
EP - 58
JO - Genomics, Proteomics and Bioinformatics
JF - Genomics, Proteomics and Bioinformatics
IS - 1
ER -