Restoration of tear secretion in a murine dry eye model by oral administration of palmitoleic acid

Shigeru Nakamura, Yuki Kimura, Daisuke Mori, Toshihiro Imada, Yusuke Izuta, Michiko Shibuya, Hisayo Sakaguchi, Erina Oonishi, Naoko Okada, Kenji Matsumoto, Kazuo Tsubota

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Sea buckthorn (Hippophae rhamnoides)–derived products have traditionally been used as food and medicinal ingredients in Eastern countries. The purpose of this study was to investigate the effect of oral intake of sea buckthorn oil products on tear secretion using a murine dry eye model. Orally administered sea buckthorn pulp oil (not seed oil) restored aqueous tear secretion to its normal value under a dry eye condition. Palmitoleate (C16:1), a fatty acid present in sea buckthorn pulp oil, preserved tear secretion and suppressed inflammatory cytokines in the lacrimal gland to the same extent as that by pulp oil. These results suggest that an oral intake of sea buckthorn pulp oil has a potency to preserve tear secretion capacity in the dry eye state and palmitoleate, its main constituent fatty acid, is an active component of the oil. This effect may enable a potent diet‐based treatment for the prevention of dry eye.

Original languageEnglish
Article number364
Issue number4
Publication statusPublished - 2017 Apr 5


  • Dry eye
  • Fatty acid
  • Ophthalmology

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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