Review of acquired cystic disease-associated renal cell carcinoma with focus on pathobiological aspects

Naoto Kuroda, Chisato Ohe, Shuji Mikami, Ondrej Hes, Michal Michal, Matteo Brunelli, Guido Martignoni, Yasuharu Sato, Tadashi Yoshino, Yoshiyuki Kakehi, Taro Shuin, Gang Hong Lee

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)


Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) is a recently established entity. In this article, we introduce the general view of this new entity. Macroscopically, the disease exclusively occurs in ACD and may arise as a dominant mass or non-dominant masses. Histologically, the tumor is characterized by a microcystic pattern, neoplastic cells with an eosinophilic or oncocytic cytoplasm and frequent intratumoral oxalate crystal deposition. Prominent nucleoli of tumor cells are often observed. Immunohistochemically, neoplastic cells are generally positive for AMACR but negative for cytokeratin 7. Ultrastructurally, neoplastic cells contain abundant mitochondria in the cytoplasm. Genetically, the gain of chromosomes 3, 7, 17 and abnormality of the sex chromosome were frequently observed in several studies. In conclusion, ACD-associated RCC may be widely recognized as a distinct entity in the near future because this tumor is morphologically and genetically different from other renal tumor entities that have been previously established.

Original languageEnglish
Pages (from-to)1215-1218
Number of pages4
JournalHistology and Histopathology
Issue number9
Publication statusPublished - 2011 Sept
Externally publishedYes


  • Acquired cystic disease-associated renal cell carcinoma
  • Chromosome 3
  • Oxalate crystals
  • Sex chromosome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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