Review of diagnosis and clinical course of retinoblastoma

Mayo Nozaki, Satoru Kase, Kazuhiko Yoshida, Kan Ishijima, Mika Noda, Shigenobu Suzuki, Noriyuki Azuma, Susumu Ishida

Research output: Contribution to journalReview articlepeer-review


Purpose: To report 7 cases of retinoblastoma regarding initial diagnosis and clinical course. Cases: A retrospective study was made on 7 cases seen during the past 8 years. Results: The series comprised 2 boys and 5 girls. Five cases were unilaterally and two were bilaterally affected. Six cases were younger than 4 years and one was 7 years at the initial diagnosis. Chief complaints comprised leukocoria and squint in 5 cases, impaired vision in one, and hyperemia with edema of eyelid in one. Retinoblastoma was classified from stage B to E. Three eyes were in stage E at the time of diagnosis. Enucleation was performed in 5 eyes and orbital exenteration in one as the initial treatment. Enucleation became necessary in 2 out of 3 eyes that were conservatively treated. There was no metastasis in 6 eyes that received enucleation or exenteration. Two cases that developed extraocular infiltration resulted in fetal outcome. Initial clinical features in these 2 cases did not match with the final outcome. Conclusion: Clinical features of retinoblastoma at the initial diagnosis are not indicative of prognosis.

Original languageEnglish
Pages (from-to)1123-1127
Number of pages5
JournalJapanese Journal of Clinical Ophthalmology
Issue number7
Publication statusPublished - 2011 Jul 15
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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