Review of molecular modification techniques for improved detection of biomolecules by mass spectrometry

Aki Honda; Yoshio Suzuki; Koji Suzuki

doi:10.1016/j.aca.2008.05.064

Review of molecular modification techniques for improved detection of biomolecules by mass spectrometry

Aki Honda, Yoshio Suzuki, Koji Suzuki

Department of Applied Chemistry

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

After a soft ionizing method was established, MS (mass spectrometry) has become a more common tool in biochemistry because soft ionization made it possible to detect large molecules such as proteins. Many kinds of applications were established to further utilize MS for the identification or quantitation of biomolecules. In this review, we introduce recent applications with special focus on chemical modification techniques and chemical probes developed for the MS determination of biomolecules.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Analytica Chimica Acta
Volume	623
Issue number	1
DOIs	https://doi.org/10.1016/j.aca.2008.05.064
Publication status	Published - 2008 Aug 8

Keywords

Biomolecules
Chemical modification
Mass probe
Mass spectrometry

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Environmental Chemistry
Spectroscopy

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10.1016/j.aca.2008.05.064

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abstract = "After a soft ionizing method was established, MS (mass spectrometry) has become a more common tool in biochemistry because soft ionization made it possible to detect large molecules such as proteins. Many kinds of applications were established to further utilize MS for the identification or quantitation of biomolecules. In this review, we introduce recent applications with special focus on chemical modification techniques and chemical probes developed for the MS determination of biomolecules.",

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AU - Honda, Aki

AU - Suzuki, Yoshio

AU - Suzuki, Koji

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AB - After a soft ionizing method was established, MS (mass spectrometry) has become a more common tool in biochemistry because soft ionization made it possible to detect large molecules such as proteins. Many kinds of applications were established to further utilize MS for the identification or quantitation of biomolecules. In this review, we introduce recent applications with special focus on chemical modification techniques and chemical probes developed for the MS determination of biomolecules.

KW - Biomolecules

KW - Chemical modification

KW - Mass probe

KW - Mass spectrometry

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Review of molecular modification techniques for improved detection of biomolecules by mass spectrometry

Abstract

Keywords

ASJC Scopus subject areas

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