Review of the treatment of non-small cell lung cancer with gefitinib

Takuya Araki, Hideaki Yashima, Kimihiro Shimizu, Tohru Aomori, Tadahiro Hashita, Kyoichi Kaira, Tomonori Nakamura, Koujirou Yamamoto

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)


In the past decade, molecular-targeted drugs have been focused upon for the treatment of cancer. In 2002, gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor became available in Japan for the treatment of non-small cell lung cancer (NSCLC). Over 80% of selected patients, such as EGFR mutation-positive patients, respond to gefitinib treatment; however, most patients develop acquired resistance to gefitinib within a few years. Recently, many studies have been performed to determine precisely how to select patients who will respond to gefitinib, the best timing for its administration, and how to avoid the development of acquired resistance as well as adverse drug effects. This article reviews the use of gefitinib for the treatment of NSCLC from a pharmaceutical viewpoint.

Original languageEnglish
Pages (from-to)407-421
Number of pages15
JournalClinical Medicine Insights: Oncology
Publication statusPublished - 2012
Externally publishedYes


  • EGFR
  • Gefitinib
  • KRAS
  • Lung cancer

ASJC Scopus subject areas

  • Oncology


Dive into the research topics of 'Review of the treatment of non-small cell lung cancer with gefitinib'. Together they form a unique fingerprint.

Cite this