TY - JOUR
T1 - Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients
T2 - A new classification from the European Society for Blood and Marrow Transplantation
AU - Mohty, M.
AU - Malard, F.
AU - Abecassis, M.
AU - Aerts, E.
AU - Alaskar, A. S.
AU - Aljurf, M.
AU - Arat, M.
AU - Bader, P.
AU - Baron, F.
AU - Bazarbachi, A.
AU - Blaise, D.
AU - Ciceri, F.
AU - Corbacioglu, S.
AU - Dalle, J. H.
AU - Dignan, F.
AU - Fukuda, T.
AU - Huynh, A.
AU - Masszi, T.
AU - Michallet, M.
AU - Nagler, A.
AU - NiChonghaile, M.
AU - Okamoto, S.
AU - Pagliuca, A.
AU - Peters, C.
AU - Petersen, F. B.
AU - Richardson, P. G.
AU - Ruutu, T.
AU - Savani, B. N.
AU - Wallhult, E.
AU - Yakoub-Agha, I.
AU - Duarte, R. F.
AU - Carreras, E.
N1 - Publisher Copyright:
© 2016 Macmillan Publishers Limited.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.
AB - Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.
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U2 - 10.1038/bmt.2016.130
DO - 10.1038/bmt.2016.130
M3 - Article
C2 - 27183098
AN - SCOPUS:84968571756
SN - 0268-3369
VL - 51
SP - 906
EP - 912
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 7
ER -