Revolutionary change in rheumatoid arthritis management with biological therapy

Tsutomu Takeuchi

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)


Biological agents targeting a specific molecule have extraordinarily fine specificity and powerful functional capabilities. By the introduction of biological therapy, management of rheumatoid arthritis has undergone a revolution and a paradigm shift. In this review, I will summarize the role in the pathogenesis of rheumatoid arthritis of the molecules targeted by biological agents. Providing evidence obtained in clinical trials and investigator-initiated clinical studies in Japan, the effectiveness and safety of biological therapy in rheumatoid arthritis are discussed. Finally, studies aiming at a personalized strategy with biological agents are listed and the future perspectives toward tailor-made medicine in the field of rheumatology are discussed.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalKeio Journal of Medicine
Issue number3
Publication statusPublished - 2011 Jun
Externally publishedYes


  • IL-6
  • Remission
  • Safety
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Medicine(all)


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