TY - JOUR
T1 - Rhodium-Catalyzed Anti-Markovnikov Hydroamination of Aliphatic and Aromatic Terminal Alkynes with Aliphatic Primary Amines
AU - Morimoto, Yoshihiko
AU - Kochi, Takuya
AU - Kakiuchi, Fumitoshi
N1 - Funding Information:
F.K. acknowledges financial support, in part, from the Japanese Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research 21H01944, Japan. Y.M. is also grateful for support by the Research Grant of Keio Leading-edge Laboratory of Science & Technology and Research Grant of Keio Research Development and Sponsored Projects, Faculty of Science & Technology.
Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/9/17
Y1 - 2021/9/17
N2 - Anti-Markovnikov hydroamination of both aliphatic and aromatic terminal alkynes with primary amines was achieved using an 8-quinolinolato rhodium catalyst to form aldimines and enamines in high yields. This catalytic system realized high functional group tolerance including hydroxy, bromo, cyano, and thioester groups.
AB - Anti-Markovnikov hydroamination of both aliphatic and aromatic terminal alkynes with primary amines was achieved using an 8-quinolinolato rhodium catalyst to form aldimines and enamines in high yields. This catalytic system realized high functional group tolerance including hydroxy, bromo, cyano, and thioester groups.
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U2 - 10.1021/acs.joc.1c01636
DO - 10.1021/acs.joc.1c01636
M3 - Article
AN - SCOPUS:85115648695
SN - 0022-3263
VL - 86
SP - 13143
EP - 13152
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 18
ER -