Rhodium-catalyzed reaction of N-acylpiperazines with CO and ethylene. Carbonylation at a C-H bond directed by an amido group

Yutaka Ishii; Naoto Chatani; Fumitoshi Kakiuchi; Shinji Murai

doi:10.1016/S0040-4039(97)01738-3

Rhodium-catalyzed reaction of N-acylpiperazines with CO and ethylene. Carbonylation at a C-H bond directed by an amido group

Yutaka Ishii, Naoto Chatani, Fumitoshi Kakiuchi, Shinji Murai

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

The reaction of N-acylpiperazines with CO (15 atm) and ethylene at 160°C in the presence of Rh₄(CO)₁₂ results in dehydrogenation and carbonylation at a C-H bond. This reaction represents the first example of carbonylation at a C-H bond promoted by an oxygen functional group.

Original language	English
Pages (from-to)	7565-7568
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	43
DOIs	https://doi.org/10.1016/S0040-4039(97)01738-3
Publication status	Published - 1997 Oct 27
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(97)01738-3

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title = "Rhodium-catalyzed reaction of N-acylpiperazines with CO and ethylene. Carbonylation at a C-H bond directed by an amido group",

abstract = "The reaction of N-acylpiperazines with CO (15 atm) and ethylene at 160°C in the presence of Rh4(CO)12 results in dehydrogenation and carbonylation at a C-H bond. This reaction represents the first example of carbonylation at a C-H bond promoted by an oxygen functional group.",

author = "Yutaka Ishii and Naoto Chatani and Fumitoshi Kakiuchi and Shinji Murai",

note = "Funding Information: This work is partially supported by grants from the Ministry of Education, Science, and Culture, Japan.",

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T1 - Rhodium-catalyzed reaction of N-acylpiperazines with CO and ethylene. Carbonylation at a C-H bond directed by an amido group

AU - Ishii, Yutaka

AU - Chatani, Naoto

AU - Kakiuchi, Fumitoshi

AU - Murai, Shinji

N1 - Funding Information: This work is partially supported by grants from the Ministry of Education, Science, and Culture, Japan.

PY - 1997/10/27

Y1 - 1997/10/27

N2 - The reaction of N-acylpiperazines with CO (15 atm) and ethylene at 160°C in the presence of Rh4(CO)12 results in dehydrogenation and carbonylation at a C-H bond. This reaction represents the first example of carbonylation at a C-H bond promoted by an oxygen functional group.

AB - The reaction of N-acylpiperazines with CO (15 atm) and ethylene at 160°C in the presence of Rh4(CO)12 results in dehydrogenation and carbonylation at a C-H bond. This reaction represents the first example of carbonylation at a C-H bond promoted by an oxygen functional group.

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U2 - 10.1016/S0040-4039(97)01738-3

DO - 10.1016/S0040-4039(97)01738-3

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

Rhodium-catalyzed reaction of N-acylpiperazines with CO and ethylene. Carbonylation at a C-H bond directed by an amido group

Abstract

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