(+)-Rhododendrol and epi-rhododendrin suppress the no production by activated macrophages in vivo

Shinji Fushiya, Yasuaki Kabe, Yasuaki Ikegaya, Fumihide Takano

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22 Citations (Scopus)


In this study, we investigated the effect of (+)-rhododendrol (1) and epi-rhododendrin (2) isolated from Acer nikoense Maxim. (Aceraceae) on nitric oxide (NO) production in mouse peritoneal macrophages elicited by bacillus Calmette-Guerin and in vitro stimulated by lipopolysaccharide. The NO production was not affected by an oral administration of methanol extract at a dose of 100 mg/kg/day. However, the AcOEt soluble fraction significantly reduced the NO production. (+)-Rhododendrol (1) isolated as an active substance from the AcOEt fraction suppressed the NO production. epi- Rhododendrin (2), the glucoside of (+)-rhododendrol (1) isolated from the n- BuOH fraction, also suppressed the NO production. As NO is one of the critical mediators in inflammation, these results suggest that (+)- rhododendrol (1) and epi-rhododendrin (2) contribute in part to the anti- inflammatory effect of A. nikoense.

Original languageEnglish
Pages (from-to)598-602
Number of pages5
JournalPlanta Medica
Issue number7
Publication statusPublished - 1998
Externally publishedYes


  • (+)-rhododendrol
  • Acer nikoense
  • Aceraceae
  • Epirhododendrin
  • Inflammation
  • Macrophage
  • Nitric oxide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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