Ribonuclease inhibitor and angiogenin system regulates cell type–specific global translation

Martina Stillinovic; Mayuresh Anant Sarangdhar; Nicola Andina; Aubry Tardivel; Frédéric Greub; Giuseppe Bombaci; Camille Ansermet; Marco Zatti; Dipanjali Saha; Jieyu Xiong; Takeru Sagae; Mariko Yokogawa; Masanori Osawa; Manfred Heller; Adrian Keogh; Irene Keller; Anne Angelillo-Scherrer; Ramanjaneyulu Allam

doi:10.1126/sciadv.adl0320

Ribonuclease inhibitor and angiogenin system regulates cell type–specific global translation

Martina Stillinovic, Mayuresh Anant Sarangdhar, Nicola Andina, Aubry Tardivel, Frédéric Greub, Giuseppe Bombaci, Camille Ansermet, Marco Zatti, Dipanjali Saha, Jieyu Xiong, Takeru Sagae, Mariko Yokogawa, Masanori Osawa, Manfred Heller, Adrian Keogh, Irene Keller, Anne Angelillo-Scherrer, Ramanjaneyulu Allam

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Translation of mRNAs is a fundamental process that occurs in all cell types of multicellular organisms. Conventionally, it has been considered a default step in gene expression, lacking specific regulation. However, recent studies have documented that certain mRNAs exhibit cell type–specific translation. Despite this, it remains unclear whether global translation is controlled in a cell type–specific manner. By using human cell lines and mouse models, we found that deletion of the ribosome-associated protein ribonuclease inhibitor 1 (RNH1) decreases global translation selectively in hematopoietic-origin cells but not in the non–hematopoietic-origin cells. RNH1-mediated cell type–specific translation is mechanistically linked to angiogenin-induced ribosomal biogenesis. Collectively, this study unravels the existence of cell type–specific global translation regulators and highlights the complex translation regulation in vertebrates.

Original language	English
Article number	eadl0320
Journal	Science Advances
Volume	10
Issue number	22
DOIs	https://doi.org/10.1126/sciadv.adl0320
Publication status	Published - 2024 May

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Stillinovic, M., Sarangdhar, M. A., Andina, N., Tardivel, A., Greub, F., Bombaci, G., Ansermet, C., Zatti, M., Saha, D., Xiong, J., Sagae, T., Yokogawa, M., Osawa, M., Heller, M., Keogh, A., Keller, I., Angelillo-Scherrer, A., & Allam, R. (2024). Ribonuclease inhibitor and angiogenin system regulates cell type–specific global translation. Science Advances, 10(22), Article eadl0320. https://doi.org/10.1126/sciadv.adl0320

Stillinovic, M, Sarangdhar, MA, Andina, N, Tardivel, A, Greub, F, Bombaci, G, Ansermet, C, Zatti, M, Saha, D, Xiong, J, Sagae, T, Yokogawa, M , Osawa, M, Heller, M, Keogh, A, Keller, I, Angelillo-Scherrer, A & Allam, R 2024, 'Ribonuclease inhibitor and angiogenin system regulates cell type–specific global translation', Science Advances, vol. 10, no. 22, eadl0320. https://doi.org/10.1126/sciadv.adl0320

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title = "Ribonuclease inhibitor and angiogenin system regulates cell type–specific global translation",

abstract = "Translation of mRNAs is a fundamental process that occurs in all cell types of multicellular organisms. Conventionally, it has been considered a default step in gene expression, lacking specific regulation. However, recent studies have documented that certain mRNAs exhibit cell type–specific translation. Despite this, it remains unclear whether global translation is controlled in a cell type–specific manner. By using human cell lines and mouse models, we found that deletion of the ribosome-associated protein ribonuclease inhibitor 1 (RNH1) decreases global translation selectively in hematopoietic-origin cells but not in the non–hematopoietic-origin cells. RNH1-mediated cell type–specific translation is mechanistically linked to angiogenin-induced ribosomal biogenesis. Collectively, this study unravels the existence of cell type–specific global translation regulators and highlights the complex translation regulation in vertebrates.",

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AU - Stillinovic, Martina

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AU - Greub, Frédéric

AU - Bombaci, Giuseppe

AU - Ansermet, Camille

AU - Zatti, Marco

AU - Saha, Dipanjali

AU - Xiong, Jieyu

AU - Sagae, Takeru

AU - Yokogawa, Mariko

AU - Osawa, Masanori

AU - Heller, Manfred

AU - Keogh, Adrian

AU - Keller, Irene

AU - Angelillo-Scherrer, Anne

AU - Allam, Ramanjaneyulu

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AB - Translation of mRNAs is a fundamental process that occurs in all cell types of multicellular organisms. Conventionally, it has been considered a default step in gene expression, lacking specific regulation. However, recent studies have documented that certain mRNAs exhibit cell type–specific translation. Despite this, it remains unclear whether global translation is controlled in a cell type–specific manner. By using human cell lines and mouse models, we found that deletion of the ribosome-associated protein ribonuclease inhibitor 1 (RNH1) decreases global translation selectively in hematopoietic-origin cells but not in the non–hematopoietic-origin cells. RNH1-mediated cell type–specific translation is mechanistically linked to angiogenin-induced ribosomal biogenesis. Collectively, this study unravels the existence of cell type–specific global translation regulators and highlights the complex translation regulation in vertebrates.

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Ribonuclease inhibitor and angiogenin system regulates cell type–specific global translation

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