TY - JOUR
T1 - Risk of tuberculosis infection among health care workers and nursing students in Japan
AU - Nishimura, Tomoyasu
AU - Ota, Masaki
AU - Mori, Masaaki
AU - Fujiwara, Hiroshi
AU - Takano, Yaoko
AU - Kato, Seiya
AU - Kawabe, Hiroshi
AU - Hasegawa, Naoki
N1 - Funding Information:
The authors thank the health care workers of Keio University hospital who participated in this study. This work was supported by the Japan Society for the Promotion of Science [ KAKENHI 16K09942 to T.N. ] and Keio Gijuku Academic Development Funds [T.N.].
Funding Information:
The authors thank the health care workers of Keio University hospital who participated in this study. This work was supported by the Japan Society for the Promotion of Science [KAKENHI 16K09942 to T.N.] and Keio Gijuku Academic Development Funds [T.N.].
Publisher Copyright:
© 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases
PY - 2018/11
Y1 - 2018/11
N2 - It is important to evaluate the risk of tuberculosis (TB) infection among health care workers (HCWs) and nursing students in Japan to propose the optimal countermeasure against new TB infection for them. To estimate the annual incidence of TB infection in HCWs at a Japanese university hospital without TB wards and in nursing students at a Japanese university using interferon-gamma release assay (IGRA). Serial IGRAs were prospectively conducted on the HCWs between August 2010 and December 2015. For nursing students, two IGRA tests were conducted before commencement of clinical training and at employment as nurses between April 2007 and December 2015. A total of 328 HCWs and 298 nursing students were followed for 670.15 and 1212.80 person-years, respectively. Assuming IGRA-positive conversions were all attributable to true infection, the incidence of TB infection in HCWs and nursing students was 0.149/100 and 0.0825/100 person-years, respectively. At a Japanese university hospital without TB wards and a Japanese university, the annual incidence of TB infection among HCWs and nursing students estimated from serial IGRA results was low, but continued vigilance for the prevention of TB infection is essential.
AB - It is important to evaluate the risk of tuberculosis (TB) infection among health care workers (HCWs) and nursing students in Japan to propose the optimal countermeasure against new TB infection for them. To estimate the annual incidence of TB infection in HCWs at a Japanese university hospital without TB wards and in nursing students at a Japanese university using interferon-gamma release assay (IGRA). Serial IGRAs were prospectively conducted on the HCWs between August 2010 and December 2015. For nursing students, two IGRA tests were conducted before commencement of clinical training and at employment as nurses between April 2007 and December 2015. A total of 328 HCWs and 298 nursing students were followed for 670.15 and 1212.80 person-years, respectively. Assuming IGRA-positive conversions were all attributable to true infection, the incidence of TB infection in HCWs and nursing students was 0.149/100 and 0.0825/100 person-years, respectively. At a Japanese university hospital without TB wards and a Japanese university, the annual incidence of TB infection among HCWs and nursing students estimated from serial IGRA results was low, but continued vigilance for the prevention of TB infection is essential.
KW - Health care worker
KW - Interferon-gamma release assay
KW - Latent tuberculosis infection
KW - Nursing student
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U2 - 10.1016/j.jiac.2018.08.006
DO - 10.1016/j.jiac.2018.08.006
M3 - Article
C2 - 30181031
AN - SCOPUS:85052727918
SN - 1341-321X
VL - 24
SP - 921
EP - 924
JO - Journal of Infection and Chemotherapy
JF - Journal of Infection and Chemotherapy
IS - 11
ER -
