Risk Prediction Model of 90-Day Mortality after Esophagectomy for Cancer

Xavier Benoit D'Journo, David Boulate, Alex Fourdrain, Anderson Loundou, Mark I. Van Berge Henegouwen, Suzanne S. Gisbertz, J. Robert O'Neill, Arnulf Hoelscher, Guillaume Piessen, Jan Van Lanschot, Bas Wijnhoven, Blair Jobe, Andrew Davies, Paul M. Schneider, Manuel Pera, Magnus Nilsson, Philippe Nafteux, Yuko Kitagawa, Christopher R. Morse, Wayne HofstetterDaniela Molena, Jimmy Bok Yan So, Arul Immanuel, Simon L. Parsons, Michael Hareskov Larsen, James P. Dolan, Stephanie G. Wood, Nick Maynard, Mark Smithers, Sonia Puig, Simon Law, Ian Wong, Andrew Kennedy, Wang Kangning, John V. Reynolds, C. S. Pramesh, Mark Ferguson, Gail Darling, Wolfgang Schröder, Marc Bludau, Tim Underwood, Richard Van Hillegersberg, Andrew Chang, Ivan Cecconello, Ulysses Ribeiro, Giovanni De Manzoni, Riccardo Rosati, Madhankumar Kuppusamy, Pascal Alexandre Thomas, Donald E. Low

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Importance: Ninety-day mortality rates after esophagectomy are an indicator of the quality of surgical oncologic management. Accurate risk prediction based on large data sets may aid patients and surgeons in making informed decisions. Objective: To develop and validate a risk prediction model of death within 90 days after esophagectomy for cancer using the International Esodata Study Group (IESG) database, the largest existing prospective, multicenter cohort reporting standardized postoperative outcomes. Design, Setting, and Participants: In this diagnostic/prognostic study, we performed a retrospective analysis of patients from 39 institutions in 19 countries between January 1, 2015, and December 31, 2019. Patients with esophageal cancer were randomly assigned to development and validation cohorts. A scoring system that predicted death within 90 days based on logistic regression ß coefficients was conducted. A final prognostic score was determined and categorized into homogeneous risk groups that predicted death within 90 days. Calibration and discrimination tests were assessed between cohorts. Exposures: Esophageal resection for cancer of the esophagus and gastroesophageal junction. Main Outcomes and Measures: All-cause postoperative 90-day mortality. Results: A total of 8403 patients (mean [SD] age, 63.6 [9.0] years; 6641 [79.0%] male) were included. The 30-day mortality rate was 2.0% (n = 164), and the 90-day mortality rate was 4.2% (n = 353). Development (n = 4172) and validation (n = 4231) cohorts were randomly assigned. The multiple logistic regression model identified 10 weighted point variables factored into the prognostic score: age, sex, body mass index, performance status, myocardial infarction, connective tissue disease, peripheral vascular disease, liver disease, neoadjuvant treatment, and hospital volume. The prognostic scores were categorized into 5 risk groups: very low risk (score, =1; 90-day mortality, 1.8%), low risk (score, 0; 90-day mortality, 3.0%), medium risk (score, -1 to -2; 90-day mortality, 5.8%), high risk (score, -3 to -4: 90-day mortality, 8.9%), and very high risk (score, =-5; 90-day mortality, 18.2%). The model was supported by nonsignificance in the Hosmer-Lemeshow test. The discrimination (area under the receiver operating characteristic curve) was 0.68 (95% CI, 0.64-0.72) in the development cohort and 0.64 (95% CI, 0.60-0.69) in the validation cohort. Conclusions and Relevance: In this study, on the basis of preoperative variables, the IESG risk prediction model allowed stratification of an individual patient's risk of death within 90 days after esophagectomy. These data suggest that this model can help in the decision-making process when esophageal cancer surgery is being considered and in informed consent.

Original languageEnglish
Pages (from-to)836-845
Number of pages10
JournalJAMA Surgery
Issue number9
Publication statusPublished - 2021 Sept

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Risk Prediction Model of 90-Day Mortality after Esophagectomy for Cancer'. Together they form a unique fingerprint.

Cite this