Risperidone-associated urinary incontinence in patients with autistic disorder with mental retardation

Hirokazu Kumazaki, Koichiro Watanabe, Yasushi Imasaka, Kazuhiko Iwata, Akemi Tomoda, Masaru Mimura

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


We report several cases in which patients with autistic disorder with mental retardation who received risperidone experienced urinary incontinence. We retrospectively investigated the medical records of patients housed in facilities for patients with autistic disorder with mental retardation. Those who had undergone a medical examination at a hospital in Tokyo from April 1999 to March 2009 were included in the study.Retrospective data were gathered including age, sex, IQ, birth weight, dosage of risperidone, urinary density, as well as existence of urinary and fecal incontinence. We divided the participants into those who did and did not experience urinary incontinence after taking risperidone and compared the 2 groups. Risperidone had been prescribed to 35 patients. In spite of the fact that no patient had a history of urinary incontinence, 14 patients experienced urinary incontinence after receiving risperidone. Moreover, 4 of these 14 patients also had fecal incontinence. Among the variables we examined, the only significant difference between groups was in sex, with significantly more women experiencing incontinence compared with men. When the dose of risperidone was reduced or the patients switched to other drugs, urinary incontinence of the patients improved.Hence, risperidone may have a casual relationship with urinary incontinence. Further research is needed to understand the pathophysiology of possible effect.

Original languageEnglish
Pages (from-to)624-626
Number of pages3
JournalJournal of clinical psychopharmacology
Issue number5
Publication statusPublished - 2014 Oct


  • autistic disorder
  • mental retardation
  • risperidone
  • sex
  • urinary incontinence

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)


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