TY - JOUR
T1 - Role of 5-hydroxytryptamine in the progression of monocrotaline induced pulmonary hypertension in rats
AU - Kanai, Yae
AU - Hori, Shingo
AU - Tanaka, Tsuyoshi
AU - Yasuoka, Megumi
AU - Watanabe, Kazuo
AU - Aikawa, Naoki
AU - Hosoda, Yasuhiro
PY - 1993/9
Y1 - 1993/9
N2 - Objective: The aim was to clarify the role of serotonin (5-hydroxytryptamine, 5-HT) in monocrotaline induced pulmonary hypertension. Methods: Plasma 5-HT levels, pulmonary capillary platelet count, and vascular responsiveness to 5-HT were evaluated in the model. The effects of the selective 5-HT2 receptor antagonist, DV- 7028, on the development of pulmonary hypertension were also investigated. Results: Plasma 5-HT was raised 12 h to 3 d after monocrotaline administration (60 mg·kg-1), coinciding with accumulation of platelets in the pulmonary circulation. Isolated pulmonary arteries showed hyperreactivity to 5-HT at 14 and 21 d after monocrotaline. Administration of DV-7028 (20 mg·kg-1·d-1) attenuated the increase in pulmonary arterial pressure, right ventricular hypertrophy, and medial thickening of the pulmonary arteries. Conclusions: The present study suggests that 5-HT released from platelets contributes to the initiation and progression of monocrotaline induced pulmonary hypertension.Cardiovascular Research 1993;27:1619-1623.
AB - Objective: The aim was to clarify the role of serotonin (5-hydroxytryptamine, 5-HT) in monocrotaline induced pulmonary hypertension. Methods: Plasma 5-HT levels, pulmonary capillary platelet count, and vascular responsiveness to 5-HT were evaluated in the model. The effects of the selective 5-HT2 receptor antagonist, DV- 7028, on the development of pulmonary hypertension were also investigated. Results: Plasma 5-HT was raised 12 h to 3 d after monocrotaline administration (60 mg·kg-1), coinciding with accumulation of platelets in the pulmonary circulation. Isolated pulmonary arteries showed hyperreactivity to 5-HT at 14 and 21 d after monocrotaline. Administration of DV-7028 (20 mg·kg-1·d-1) attenuated the increase in pulmonary arterial pressure, right ventricular hypertrophy, and medial thickening of the pulmonary arteries. Conclusions: The present study suggests that 5-HT released from platelets contributes to the initiation and progression of monocrotaline induced pulmonary hypertension.Cardiovascular Research 1993;27:1619-1623.
KW - DV-7028
KW - Monocrotaline
KW - Pulmonary hypertension
KW - Serotonin
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U2 - 10.1093/cvr/27.9.1619
DO - 10.1093/cvr/27.9.1619
M3 - Article
C2 - 8287439
AN - SCOPUS:85047675987
SN - 0008-6363
VL - 27
SP - 1619
EP - 1623
JO - Cardiovascular Research
JF - Cardiovascular Research
IS - 9
ER -