Role of apoptosis in Helicobacter pylori-associated gastric mucosal injury

Hidekazu Suzuki, Hiromasa Ishii

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)


Apoptosis, a programmed cell death, was ignored, just like Helicobacter pylori, only to reappear recently. However, the number of current publications dealing with apoptosis or H. pylori has increased exponentially. Although gastric epithelial apoptosis is a programmed physiological event in the superficial aspect of the mucosa and is important for healthy cell turnover, H. pylori infection reportedly promotes such a cell death sequence. Because apoptosis regulates the cycle of cell turnover in balance with proliferation, dysregulation of apoptosis or proliferation evoked by H. pylori colonization would be linked to the gastric carcinogenesis. In other words, a reduced level of apoptosis could contribute to the generation of gastric cancer. Herein, we review apoptosis as well as its associated pathological events, such as hyperproliferation, in H. pylori-colonized gastric mucosa. (C) 2000 Blackwell Science Asia Pty Ltd.

Original languageEnglish
Pages (from-to)D46-D54
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue numberSUPPL.
Publication statusPublished - 2000
Externally publishedYes


  • Caspase
  • Gastric cancer
  • Inflammation
  • Oxygen radical
  • Proliferation

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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