Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells

Mitsuru Yagi, Takeshi Miyamoto, Yoshiaki Toyama, Toshio Suda

Research output: Contribution to journalShort surveypeer-review

99 Citations (Scopus)


Osteoclasts are the only cells that can resorb bone matrix physiologically and maintain the bone content. Osteoclasts are derived from macrophage/monocyte lineage cells; stimulation by macrophage colony stimulating factor and receptor activator of NFκB ligand induces osteoclastogenesis. During osteoclastogenesis, preosteoclasts fuse to form multinuclear mature osteoclasts. Cellular fusion is a unique phenomenon and enables fertilization, myotube formation, and efficient bone resorption in vertebrates. To date, several molecules have been reported to be fusion related in osteoclasts, namely CD44, CD47, ADAM12, MCP-1, and CD9, although the molecules which regulate osteoclast cellular fusion remain unclear. Here, we show that the seven-transmembrane- region receptor dendritic cell-specific transmembrane protein (DC-STAMP) is required for cell-cell fusion of osteoclasts and foreign body giant cells.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalJournal of Bone and Mineral Metabolism
Issue number5
Publication statusPublished - 2006 Sept
Externally publishedYes


  • Foreign body giant cell
  • Fusion
  • Macrophage
  • Osteoclast

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology


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