Role of micrornas-221/222 in digestive systems

Juntaro Matsuzaki, Hidekazu Suzuki

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are frequently upregulated in several types of human tumors, such as esophageal adenocarcinoma, gastric adenocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, and pancreatic ductal adenocarcinoma. In these cancers, silencing miR-221/222 could represent a novel anti-tumor approach to inhibit tumor growth and metastasis. On the other hand, miR-221/222 also play onco-suppressive roles in cholangiocarcinoma and gastrointestinal stromal tumors (GISTs). Here we will review the roles of miR-221/222 in digestive systems and their possibility as prognostic and therapeutic tools.

Original languageEnglish
Pages (from-to)1566-1577
Number of pages12
JournalJournal of Clinical Medicine
Issue number8
Publication statusPublished - 2015 Aug 6


  • Colorectal cancer
  • Hepatocellular carcinoma
  • MicroRNA
  • Pancreatic cancer

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Role of micrornas-221/222 in digestive systems'. Together they form a unique fingerprint.

Cite this