Abstract
Reelin controls the neuronal layer formation in the developing cerebral neocortex. The Reelin glycoprotein is mainly secreted from Cajat-Retzius cells in the marginal zone, and it guides the proper aggregation of the migrating neurons in a birth-dependent "inside-out" manner. Reelin also regulates the final process of neuronal migration (terminal translocation and somal translocation) by activating integrin and N-cadherin. It is also expressed around the subventricular zone and it controls the behavior of the migrating neurons.
Original language | English |
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Pages (from-to) | 931-937 |
Number of pages | 7 |
Journal | Brain and Nerve |
Volume | 68 |
Issue number | 8 |
Publication status | Published - 2016 Aug |
Keywords
- Layer formation
- Neuronal aggregation
- Primitive cortical zone
- Reelin
- Terminal translocation
ASJC Scopus subject areas
- Clinical Neurology