Abstract
Reelin controls the neuronal layer formation in the developing cerebral neocortex. The Reelin glycoprotein is mainly secreted from Cajat-Retzius cells in the marginal zone, and it guides the proper aggregation of the migrating neurons in a birth-dependent "inside-out" manner. Reelin also regulates the final process of neuronal migration (terminal translocation and somal translocation) by activating integrin and N-cadherin. It is also expressed around the subventricular zone and it controls the behavior of the migrating neurons.
| Original language | English |
|---|---|
| Pages (from-to) | 931-937 |
| Number of pages | 7 |
| Journal | Brain and Nerve |
| Volume | 68 |
| Issue number | 8 |
| Publication status | Published - 2016 Aug |
Keywords
- Layer formation
- Neuronal aggregation
- Primitive cortical zone
- Reelin
- Terminal translocation
ASJC Scopus subject areas
- Clinical Neurology