Role of stem cells in the pathogenesis of endometriosis

Tetsuo Maruyama

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


Endometriosis can be defined as a benign estrogen-dependent disorder in which endometrium-like tissues reside outside of the uterine cavity. Studies now indicate that multiple genetic and epigenetic changes (reminiscent of neoplastic processes) are involved in the pathophysiology of endometriosis. Given the molecular similarities between endometriosis and cancer, it is reasonable to apply the cancer stem cell model concept to the pathogenesis of endometriosis. In this article, I review and discuss the stem cell model for endometriosis in which endometriosis originates from endometrial stem/progenitor cells within eutopic and ectopic sites.

Original languageEnglish
Title of host publicationEndometriosis
Subtitle of host publicationPathogenesis and Treatment
PublisherSpringer Japan
Number of pages16
ISBN (Electronic)9784431544210
ISBN (Print)4431544208, 9784431544203
Publication statusPublished - 2014 Jan 1


  • Cancer
  • Endometriosis
  • Endometrium
  • Epithelial-mesenchymal transition
  • Stem cells

ASJC Scopus subject areas

  • General Medicine


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