Role of the innate immune system in the development of chronic colitis

Takanori Kanai, Ryoichi Iiyama, Takahiro Ishikura, Koji Uraushihara, Teruji Totsuka, Motomi Yamazaki, Tetsuya Nakamura, Mamoru Watanabe

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


Based on Pasteur's work on the microbial nature of fermentation, it was widely believed that the presence of bacteria in the intestine was essential for the life of the host. It has also been known for decades that gut commensal microbes effect the activation and development of the systemic immune system through gut-associated lymphoid tissues (GALT). Recent extensive studies have shown that recognition of microbes is mediated by a set of germline-encoded receptors, Toll-like receptors (TLRs), in mammals. This article reviews the role of the innate immunity system in the development of GALT and the pathogenesis of inflammatory bowel diseases (IBD).

Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalJournal of gastroenterology
Issue numberSUPPL. 14
Publication statusPublished - 2002 Nov 1
Externally publishedYes


  • Inflammatory bowel disease
  • Innate immunity
  • MyD88
  • Peyer's patch
  • Toll-like receptor

ASJC Scopus subject areas

  • Gastroenterology


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