TY - JOUR
T1 - Role of Wnt Signaling in Mouse Fetal Skin Wound Healing
AU - Takaya, Kento
AU - Sunohara, Ayano
AU - Aramaki-hattori, Noriko
AU - Sakai, Shigeki
AU - Okabe, Keisuke
AU - Kanazawa, Hideko
AU - Asou, Toru
AU - Kishi, Kazuo
N1 - Funding Information:
Funding: This study was supported by JSPS KAKENHI (grant number JP 19H03815).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/7
Y1 - 2022/7
N2 - Wnt proteins secrete glycoproteins that are involved in various cellular processes to main-tain homeostasis during development and adulthood. However, the expression and role of Wnt in wound healing have not been fully documented. Our previous studies have shown that, in an early-stage mouse fetus, no scarring occurred after cutaneous wounding, and complete regeneration was achieved. In this study, the expression and localization of Wnt proteins in a mouse fetal-wound-healing model and their associations with scar formation were analyzed. Wnt-related molecules were detected by in-situ hybridization, immunostaining, and real-time polymerase chain reaction. The results showed altered expression of Wnt-related molecules during the wound-healing process. Moreover, scar formation was suppressed by Wnt inhibitors, suggesting that Wnt signaling may be involved in wound healing and scar formation. Thus, regulation of Wnt signaling may be a possible mechanism to control scar formation.
AB - Wnt proteins secrete glycoproteins that are involved in various cellular processes to main-tain homeostasis during development and adulthood. However, the expression and role of Wnt in wound healing have not been fully documented. Our previous studies have shown that, in an early-stage mouse fetus, no scarring occurred after cutaneous wounding, and complete regeneration was achieved. In this study, the expression and localization of Wnt proteins in a mouse fetal-wound-healing model and their associations with scar formation were analyzed. Wnt-related molecules were detected by in-situ hybridization, immunostaining, and real-time polymerase chain reaction. The results showed altered expression of Wnt-related molecules during the wound-healing process. Moreover, scar formation was suppressed by Wnt inhibitors, suggesting that Wnt signaling may be involved in wound healing and scar formation. Thus, regulation of Wnt signaling may be a possible mechanism to control scar formation.
KW - Wnt signalling
KW - regeneration
KW - scar formation
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U2 - 10.3390/biomedicines10071536
DO - 10.3390/biomedicines10071536
M3 - Article
AN - SCOPUS:85134619914
SN - 2227-9059
VL - 10
JO - Biomedicines
JF - Biomedicines
IS - 7
M1 - 1536
ER -