Roles of stem cell antigen-1 in the pulmonary endothelium

Jun Maeda, Keiko Uchida, Kazuki Kodo, Hiroyuki Yamagishi

Research output: Chapter in Book/Report/Conference proceedingChapter


There is growing evidence that resident progenitor cell populations exist in murine lung tissues and differentiate into a mesenchymal cell lineage [1, 2]. Stem cell antigen-1 (Sca-1) is a cell surface glycoprotein, initially found in murine bone marrow-derived stem cell subtypes, such as hematopoietic stem cells. Some studies showed Sca-1 expression in the pulmonary vascular endothelium of adult murine lungs [3], while a subset of Sca-1-expressing cells formed vascular-like structures under specific conditions [1].

Original languageEnglish
Title of host publicationMolecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
PublisherSpringer Singapore
Number of pages3
ISBN (Electronic)9789811511851
ISBN (Print)9789811511844
Publication statusPublished - 2020 Jan 1


  • Angiogenesis
  • Pulmonary vessels
  • Resident progenitor cell
  • Sca-1

ASJC Scopus subject areas

  • Medicine(all)


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