Roles of stem cell antigen-1 in the pulmonary endothelium

Jun Maeda; Keiko Uchida; Kazuki Kodo; Hiroyuki Yamagishi

doi:10.1007/978-981-15-1185-1_10

Roles of stem cell antigen-1 in the pulmonary endothelium

Jun Maeda, Keiko Uchida, Kazuki Kodo, Hiroyuki Yamagishi

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

There is growing evidence that resident progenitor cell populations exist in murine lung tissues and differentiate into a mesenchymal cell lineage [1, 2]. Stem cell antigen-1 (Sca-1) is a cell surface glycoprotein, initially found in murine bone marrow-derived stem cell subtypes, such as hematopoietic stem cells. Some studies showed Sca-1 expression in the pulmonary vascular endothelium of adult murine lungs [3], while a subset of Sca-1-expressing cells formed vascular-like structures under specific conditions [1].

Original language	English
Title of host publication	Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
Publisher	Springer Singapore
Pages	87-89
Number of pages	3
ISBN (Electronic)	9789811511851
ISBN (Print)	9789811511844
DOIs	https://doi.org/10.1007/978-981-15-1185-1_10
Publication status	Published - 2020 Jan 1

Keywords

Angiogenesis
Pulmonary vessels
Resident progenitor cell
Sca-1

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-981-15-1185-1_10

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AB - There is growing evidence that resident progenitor cell populations exist in murine lung tissues and differentiate into a mesenchymal cell lineage [1, 2]. Stem cell antigen-1 (Sca-1) is a cell surface glycoprotein, initially found in murine bone marrow-derived stem cell subtypes, such as hematopoietic stem cells. Some studies showed Sca-1 expression in the pulmonary vascular endothelium of adult murine lungs [3], while a subset of Sca-1-expressing cells formed vascular-like structures under specific conditions [1].

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ER -

Roles of stem cell antigen-1 in the pulmonary endothelium

Abstract

Keywords

ASJC Scopus subject areas

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