Roles of Tbx4 in the lung mesenchyme for airway and vascular development

Keiko Uchida, Yu Yoshida, Kazuki Kodo, Hiroyuki Yamagishi

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


The T-box family genes are evolutionarily conserved transcription factors. In particular, Tbx4 and Tbx5 are closely conserved and play crucial roles in development and organogenesis. Tbx4 is essential for hindlimb and allantoic vessel formation [1]. It is also highly expressed in the lung mesenchyme (Fig. 8.1), initially expressed at embryonic day (E) 9.25 and later expressed throughout murine embryogenesis [2].

Original languageEnglish
Title of host publicationMolecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
PublisherSpringer Singapore
Number of pages3
ISBN (Electronic)9789811511851
ISBN (Print)9789811511844
Publication statusPublished - 2020 Jan 1


  • Lung
  • Mesenchyme
  • Transcription factor
  • Vascular development

ASJC Scopus subject areas

  • Medicine(all)


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