RORγt-dependent IL-17A-producing cells in the pathogenesis of intestinal inflammation

T. Kanai, Y. Mikami, T. Sujino, T. Hisamatsu, T. Hibi

Research output: Contribution to journalReview articlepeer-review

64 Citations (Scopus)


The hypothesis of helper T(T h)1/T h2 cytokine balance proposed by Mosmann and Coffman is often invoked to explain the development of inflammatory diseases, including inflammatory bowel diseases (IBD). Recently, however, a newly identified class of T h cells - T h17 cells, which produce T h17 family cytokines - has been recognized as an essential subpopulation in the development of almost all kinds of human and animal inflammatory diseases, rather than T h1 and T h2 cells. A representative T h17 family cytokine, interleukin (IL)-17A, is produced by not only T h17 cells, but also by other types of cells, such as T-cell receptor γδ T cells, natural killer (NK) T cells, NK cells, myeloid cells, and innate lymphoid cells, which may also be critically involved in the initiation and persistence of IBD. Here we review recent advances in the study of such IL-17A-producing cells in the pathogenesis of IBD.

Original languageEnglish
Pages (from-to)240-247
Number of pages8
JournalMucosal Immunology
Issue number3
Publication statusPublished - 2012 May

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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