RRR-alpha-tocopherol transfer protein, major determinant of plasma vitamin E level

Hiroyuki Arai, Makoto Arita, Keizo Inoue

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


RRR-alpha-tocopherol, the most biologically active form of vitamin E, is a lipid soluble antioxidant that protects membranes from oxidative stresses. Vitamin E occurs in nature in eight different forms, but the body is enriched in RRR-alpha-tocopherol compared with other forms. Studies on the transport of vitamin E in animals and humans suggest that the liver plays a key role in the preferential retention, and subsequent distribution of RRR-alpha-tocopherol to tissues. We have purified RRR-alpha-tocopherol transfer protein (alpha-TTP) from the liver and cloned its cDNA. alpha-TTP specifically binds RRR-alpha-tocopherol and enhances its transfer between membranes. Furthermore, we have identified that alpha-TTP is abnormal in the patients with familial isolated vitamin E deficiency. The nature and physiological functions of alpha-TTP will be reviewed.

Original languageEnglish
Pages (from-to)A658
JournalFASEB Journal
Issue number5
Publication statusPublished - 1998 Mar 20
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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