Salivary flow and its relationship to oral signs and symptoms in patients with dry eyes

Mariko Koseki, Y. Maki, T. Matsukubo, Y. Ohashi, K. Tsubota

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


OBJECTIVES: The aim of this study was to investigate oral symptoms and clinical parameters in dry eye patients. Subjective reports of the sensation of a dry mouth, salivary flow rates, and clinical parameters of oral disease related to three different types of dry eye patients were examined. SUBJECTS AND METHODS: There were 224 individuals, including dry eye patients and control subjects. The dry eye patients were classified into three types: patients with Sjögren's syndrome (SS-DE), patients without SS-DE (non-SS-DE), and patients with Stevens-Johnson syndrome (SJS-DE). Salivary flow rates were measured using two kinds of sialometry. Subjective and objective oral symptoms and signs were also examined. RESULTS AND CONCLUSION: Over half of the dry eye patients complained of a dry mouth. The flow rates of their stimulated whole saliva and parotid saliva were significantly lower than those of the control groups (P < 0.05, P < 0.01). The sensation of a dry mouth and changes in oral soft tissues, dental caries, and oral Candida frequently occurred in dry eye patients.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalOral Diseases
Issue number2
Publication statusPublished - 2004 Mar
Externally publishedYes


  • Dry eye
  • Dry mouth
  • Salivary flow rate

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)


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