TY - JOUR
T1 - Saphenous vein valve assessment utilizing upright CT to potentially improve graft assessment for bypass surgery
AU - Nakahara, Takehiro
AU - Yamada, Minoru
AU - Yokoyama, Yoichi
AU - Yamada, Yoshitake
AU - Narita, Keiichi
AU - Imanishi, Nobuaki
AU - Yamazaki, Masataka
AU - Shimizu, Hideyuki
AU - Narula, Jagat
AU - Jinzaki, Masahiro
N1 - Funding Information:
This study was supported by Canon Medical Systems, Japan Society for the Promotion of Science (JSPS KAK-ENHI: Grant Number JP17H04266), Uehara Memorial Foundation, and Canon Medical Systems (Otawara, Japan) to JM.
Funding Information:
This study was supported by the Japan Society for the Promotion of Science (JSPS KAKENHI: Grant Number JP17H04266), Uehara Memorial Foundation, and Canon Medical Systems (Otawara, Japan). Masahiro Jinzaki received a grant from Canon Medical Systems. Canon Medical Systems has loaned an upright computed tomography machine to Keio University. However, Canon Medical Systems is not involved in the design and conduct of the study; in the collection, analysis, and interpretation of the data; nor the preparation, review, or approval of the manuscript. All other authors have no relationships with the industry or other entities.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Saphenous veins (SVs) are frequently employed as bypass grafts. The SV graft failure is predominantly seen at the valve site. Avoiding valves during vein harvest would help reduce graft failure. We endeavored to detect SV valves, tributaries, and vessel size employing upright computed tomography (CT) for the raw cadaver venous samples and in healthy volunteers. Five cadaver legs were scanned. Anatomical analysis showed 3.0 (IQR: 2.0–3.0) valves and 13.50 (IQR: 10.00–16.25) tributaries. The upright CT completely detected, compared to 2.0 (IQR: 1.5–2.5, p = 0.06) valves and 9.5 (IQR: 7.5–13.0, p = 0.13) tributaries by supine CT. From a total of 190 volunteers, 138 (men:75, women:63) were included. The number of valves from the SF junction to 35 cm were significantly higher in upright CT than in supine CT bilaterally [upright vs. supine, Right: 4 (IQR: 3–5) vs. 2 (IQR:1–2), p < 0.0001, Left: 4 (IQR: 3–5) vs. 2 (IQR: 1–2), p < 0.0001]. The number of tributaries and vessel areas per leg were also higher for upright compared with supine CT. Upright CT enables non-invasive detection of SV valves, tributaries, and vessel size. Although not tested here, it is expected that upright CT may potentially improve graft assessment for bypass surgery.
AB - Saphenous veins (SVs) are frequently employed as bypass grafts. The SV graft failure is predominantly seen at the valve site. Avoiding valves during vein harvest would help reduce graft failure. We endeavored to detect SV valves, tributaries, and vessel size employing upright computed tomography (CT) for the raw cadaver venous samples and in healthy volunteers. Five cadaver legs were scanned. Anatomical analysis showed 3.0 (IQR: 2.0–3.0) valves and 13.50 (IQR: 10.00–16.25) tributaries. The upright CT completely detected, compared to 2.0 (IQR: 1.5–2.5, p = 0.06) valves and 9.5 (IQR: 7.5–13.0, p = 0.13) tributaries by supine CT. From a total of 190 volunteers, 138 (men:75, women:63) were included. The number of valves from the SF junction to 35 cm were significantly higher in upright CT than in supine CT bilaterally [upright vs. supine, Right: 4 (IQR: 3–5) vs. 2 (IQR:1–2), p < 0.0001, Left: 4 (IQR: 3–5) vs. 2 (IQR: 1–2), p < 0.0001]. The number of tributaries and vessel areas per leg were also higher for upright compared with supine CT. Upright CT enables non-invasive detection of SV valves, tributaries, and vessel size. Although not tested here, it is expected that upright CT may potentially improve graft assessment for bypass surgery.
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U2 - 10.1038/s41598-021-90998-7
DO - 10.1038/s41598-021-90998-7
M3 - Article
C2 - 34078949
AN - SCOPUS:85107155400
SN - 2045-2322
VL - 11
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 11602
ER -