SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation II. Structure elucidation

Tatsuro Kawamura; Etsu Tashiro; Kazutoshi Shindo; Masaya Imoto

doi:10.1038/ja.2008.44

SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation II. Structure elucidation

Tatsuro Kawamura, Etsu Tashiro, Kazutoshi Shindo, Masaya Imoto

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Four novel triene-ansamycin group compounds, quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol, were isolated from the culture broth of Streptomyces sp. PAE37 as inhibitors of ER stress-induced XBP1 activation. The structures of quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol were determined on the basis of their spectroscopical and chemical properties. All of four possessed 21-membered macrocyclic lactams including triene moieties.

Original language	English
Pages (from-to)	312-317
Number of pages	6
Journal	Journal of Antibiotics
Volume	61
Issue number	5
DOIs	https://doi.org/10.1038/ja.2008.44
Publication status	Published - 2008 May
Externally published	Yes

Keywords

ER stress
Triene-ansamycin
XBP1

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1038/ja.2008.44

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abstract = "Four novel triene-ansamycin group compounds, quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol, were isolated from the culture broth of Streptomyces sp. PAE37 as inhibitors of ER stress-induced XBP1 activation. The structures of quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol were determined on the basis of their spectroscopical and chemical properties. All of four possessed 21-membered macrocyclic lactams including triene moieties.",

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AU - Kawamura, Tatsuro

AU - Tashiro, Etsu

AU - Shindo, Kazutoshi

AU - Imoto, Masaya

N1 - Funding Information: Acknowledgments This study was partly supported by grants

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AB - Four novel triene-ansamycin group compounds, quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol, were isolated from the culture broth of Streptomyces sp. PAE37 as inhibitors of ER stress-induced XBP1 activation. The structures of quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol were determined on the basis of their spectroscopical and chemical properties. All of four possessed 21-membered macrocyclic lactams including triene moieties.

KW - ER stress

KW - Triene-ansamycin

KW - XBP1

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SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation II. Structure elucidation

Abstract

Keywords

ASJC Scopus subject areas

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