TY - JOUR
T1 - SCE induction in human lymphocytes by combined treatment with aniline and norharman
AU - Takehisa, S.
AU - Kanaya, N.
PY - 1982/4
Y1 - 1982/4
N2 - In human blood lymphocytes, aniline was unable to induce an increase of SCEs in vitro with or without metabolic activation by S9 mix. p-Aminophenol, one of the C-hydroxylation metabolites of aniline in the body, however, increased the SCE frequencies of lymphocytes at a concentration of 10-4 M. The addition of norharman to aniline plus S9 mix increased the SCE frequencies. This increase, however, was due to the SCE-inducing activity of norharman. These data show that the addition of norharman, which enhances the sensitivity of the Salmonella/microsome test, does not produce an enhancement of the sensitivity of the SCE test.
AB - In human blood lymphocytes, aniline was unable to induce an increase of SCEs in vitro with or without metabolic activation by S9 mix. p-Aminophenol, one of the C-hydroxylation metabolites of aniline in the body, however, increased the SCE frequencies of lymphocytes at a concentration of 10-4 M. The addition of norharman to aniline plus S9 mix increased the SCE frequencies. This increase, however, was due to the SCE-inducing activity of norharman. These data show that the addition of norharman, which enhances the sensitivity of the Salmonella/microsome test, does not produce an enhancement of the sensitivity of the SCE test.
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U2 - 10.1016/0165-1218(82)90006-4
DO - 10.1016/0165-1218(82)90006-4
M3 - Article
C2 - 7099184
AN - SCOPUS:0020045760
SN - 0165-1218
VL - 101
SP - 165
EP - 172
JO - Mutation Research/Genetic Toxicology
JF - Mutation Research/Genetic Toxicology
IS - 2
ER -