Sclerosing Polycystic Adenosis Arising in the Parotid Gland Without PI3K Pathway Mutations

Akihiro Uemura, Nobuyuki Bandoh, Takashi Goto, Ryosuke Sato, Shiori Suzuki, Akinobu Kubota, Tomomi Yamaguchi, Shogo Baba, Yasutaka Kato, Hiroshi Nishihara, Yasuaki Harabuchi, Hidehiro Takei

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A 15-year-old old Japanese male with a 2-month history of swelling of his left subauricular area was admitted to our department. A thumb-sized, hard mass with mild tenderness was palpated on the left parotid gland. Ultrasonography revealed a well-circumscribed, hypoechoic mass exhibiting heterogeneity in the left parotid gland measuring 1.7 × 1.5 × 1.3 cm. Computed tomography scan revealed a well-circumscribed, solid mass exhibiting slight peripheral enhancement in the left parotid gland. Magnetic resonance imaging revealed a hypointense mass in the left parotid gland on both T1- and T2-weighted images. Clinicoradiologic findings suggested a benign or low-grade malignant parotid tumor. The patient underwent left superficial parotidectomy with adequate safety margins. The facial nerve was identified and preserved. Neither facial paralysis nor tumor recurrence was observed as of 1 year postoperatively. Histologically, the nodule consisted of a vaguely nodular arrangement of variably sized ducts and acini in a hyalinized fibrous background with focal myxoid changes. The ductal/acinar component exhibited a bilayered arrangement of cuboidal luminal and flattened abluminal cells exhibiting a variety of epithelial proliferative patterns, including micropapillary and cribriform. Areas of oncocyte-like changes with intracellular coarse eosinophilic granules, apocrine-like feature, foamy/vacuolated changes, and clear cells were noted in the proliferating epithelium. Immunohistologically, the luminal cells were positive for gross cystic disease fluid protein-15. The Ki-67 labeling index was 2–3%. The histologic features and immunohistologic profile were consistent with sclerosing polycystic adenosis. Targeted next-generation sequencing of 160 cancer-related genes using the surgical specimen revealed no mutations, including known significant mutations in PTEN, PIK3CA, or PIK3R1.

Original languageEnglish
Pages (from-to)282-287
Number of pages6
JournalHead and Neck Pathology
Issue number1
Publication statusPublished - 2022 Mar


  • Next generation sequencing
  • PI3K pathway
  • Parotid gland
  • Parotidectomy
  • Sclerosing polycystic adenosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology


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